Acid sphingomyelinase determines melanoma progression and metastatic behaviour via the microphtalmia-associated transcription factor signalling pathway (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Acid sphingomyelinase determines melanoma progression and metastatic behaviour via the microphtalmia-associated transcription factor signalling pathway (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1038/cdd.2013.173 (literal)

Alternative label

• Bizzozero L.; Cazzato D.; Cervia D.; Assi E.; Simbari F.; Pagni F.; De Palma C.; Monno A.; Verdelli C.; Querini P.R.; Russo V.; Clementi E.; Perrotta C. (2014)
  Acid sphingomyelinase determines melanoma progression and metastatic behaviour via the microphtalmia-associated transcription factor signalling pathway
  in Cell death and differentiation
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Bizzozero L.; Cazzato D.; Cervia D.; Assi E.; Simbari F.; Pagni F.; De Palma C.; Monno A.; Verdelli C.; Querini P.R.; Russo V.; Clementi E.; Perrotta C. (literal)

Pagina inizio

• 507 (literal)

Pagina fine

• 520 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84903372715&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 21 (literal)

Rivista

• Cell death and differentiation (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Scientific Institute IRCCS e Medea, Bosisio Parini, Lecco, Italy; Department of Biomedical and Clinical Sciences, Università di Milano, University Hospital L. Sacco, via G.B. Grassi 74, I-Milano-20157, Italy; Department for Innovation in Biological, Agro-food and Forest Systems, Università della Tuscia, Viterbo, Italy; Department of Biomedical Chemistry, Institute for Advanced Chemistry of Catalonia, Spanish Council for Scientific Research (IQAC-CSIC), Barcelona, Spain; Department of Pathology, Università di Milano-Bicocca, Monza, Italy; Division of Regenerative Medicine, Division of Molecular Oncology, San Raffaele Scientific Institute, Milan, Italy (literal)

Titolo

• Acid sphingomyelinase determines melanoma progression and metastatic behaviour via the microphtalmia-associated transcription factor signalling pathway (literal)

Abstract

• Melanoma is a rapidly growing and highly metastatic cancer with high mortality rates, for which a resolutive treatment is lacking. Identification of novel therapeutic strategies and biomarkers of tumour stage is thus of particular relevance. We report here on a novel biomarker and possible candidate therapeutic target, the sphingolipid metabolising enzyme acid sphingomyelinase (A-SMase). A-SMase expression correlates inversely with tumour stage in human melanoma biopsies. Studies in a mouse model of melanoma and on cell lines derived from mouse and human melanomas demonstrated that A-SMase levels of expression actually determine the malignant phenotype of melanoma cells in terms of pigmentation, tumour progression, invasiveness and metastatic ability. The action of A-SMase is mediated by the activation of the extracellular signal-regulated kinase, the subsequent proteasomal degradation of the Microphtalmia-associated transcription factor (Mitf) and inhibition of cyclin-dependent kinase 2, Bcl-2 and c-Met, downstream targets of Mitf involved in tumour cell proliferation, survival and metastatisation. © 2014 Macmillan Publishers Limited All rights reserved. (literal)

Prodotto di

• Modelli in vitro ed in vivo per lo studio di patologie (ME.P02.007.002) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• Emilio Clementi (Persona)

Insieme di parole chiave

• Keywords of "Acid sphingomyelinase determines melanoma progression and metastatic behaviour via the microphtalmia-associated transcription factor signalling pathway" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Modelli in vitro ed in vivo per lo studio di patologie (ME.P02.007.002) (Modulo)

Autore CNR di

• Emilio Clementi (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cell death and differentiation (Rivista)

Insieme di parole chiave di

• Keywords of "Acid sphingomyelinase determines melanoma progression and metastatic behaviour via the microphtalmia-associated transcription factor signalling pathway" (Insieme di parole chiave)