3D hydrogel environment rejuvenates aged pericytes for skeletal muscle tissue engineering (Articolo in rivista)

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  • 3D hydrogel environment rejuvenates aged pericytes for skeletal muscle tissue engineering (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.3389/fphys.2014.00203 (literal)
Alternative label
  • Fuoco C.; Sangalli E.; Vono R.; Testa S.; Sacchetti B.; Latronico M.V.G.; Bernardini S.; Madeddu P.; Cesareni G.; Seliktar D.; Rizzi R.; Bearzi C.; Cannata S.M.; Spinetti G.; Gargioli C. (2014)
    3D hydrogel environment rejuvenates aged pericytes for skeletal muscle tissue engineering
    in Frontiers in physiology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Fuoco C.; Sangalli E.; Vono R.; Testa S.; Sacchetti B.; Latronico M.V.G.; Bernardini S.; Madeddu P.; Cesareni G.; Seliktar D.; Rizzi R.; Bearzi C.; Cannata S.M.; Spinetti G.; Gargioli C. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
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  • 5 MAY (literal)
Rivista
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  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Biology, University of Rome 'Tor Vergata', Rome, Italy; IRCCS MultiMedica, Via Fantoli 15/16, 20139 Milano, Italy; Stem Cell Lab, Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy; Humanitas Clinical Research Center, Milan, Italy; Experimental Cardiovascular Medicine, University of Bristol, Bristol, United Kingdom; IRCCS Fondazione Santa Lucia, Rome, Italy; Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel; Cell Biology and Neurobiology Institute, National Research Council of Italy (CNR), Rome, Italy (literal)
Titolo
  • 3D hydrogel environment rejuvenates aged pericytes for skeletal muscle tissue engineering (literal)
Abstract
  • Skeletal muscle tissue engineering is a promising approach for the treatment of muscular disorders. However, the complex organization of muscle, combined with the difficulty in finding an appropriate source of regenerative cells and in providing an adequate blood supply to the engineered tissue, makes this a hard task to face. In the present work, we describe an innovative approach to rejuvenate adult skeletal muscle-derived pericytes (MP) based on the use of a PEG-based hydrogel scaffold. MP were isolated from young (piglet) and adult (boar) pigs to assess whether aging affects tissue regeneration efficiency. In vitro, MP from boars had similar morphology and colony forming capacity to piglet MP, but an impaired ability to form myotubes and capillary-like structures. However, the use of a PEG-based hydrogel to support adult MP significantly improved their myogenic differentiation and angiogenic potentials in vitro and in vivo. Thus, PEG-based hydrogel scaffolds may provide a progenitor cell \"niche\" that promotes skeletal muscle regeneration and blood vessel growth, and together with pericytes may be developed for use in regenerative applications. © 2014 Fuoco, Sangalli, Vono, Testa, Sacchetti, Latronico, Bernardini, Madeddu, Cesareni, Seliktar, Rizzi, Bearzi, Cannata, Spinetti and Gargioli. (literal)
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