Selective inhibition of miR-92 in hippocampal neurons alters contextual fear memory (Articolo in rivista)

Type
Label
  • Selective inhibition of miR-92 in hippocampal neurons alters contextual fear memory (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/hipo.22326 (literal)
Alternative label
  • Vetere G.1,2: Barbato C.1; Pezzola S.1; Frisone P.1; Aceti M.2; Ciotti M.1; Cogoni C.3; Ammassari-Teule M.1.2; Ruberti F1. (2014)
    Selective inhibition of miR-92 in hippocampal neurons alters contextual fear memory
    in Hippocampus (N.Y.N.Y., Print); J. Wiley & sons, New York (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Vetere G.1,2: Barbato C.1; Pezzola S.1; Frisone P.1; Aceti M.2; Ciotti M.1; Cogoni C.3; Ammassari-Teule M.1.2; Ruberti F1. (literal)
Pagina inizio
  • 1458 (literal)
Pagina fine
  • 1465 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • 2014 Jul 2 [Epub ahead of print] (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 24 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1 Institute of Cell Biology and Neurobiology, National Research Council, Roma, Italy. 2 Fondazione Santa Lucia Via del Fosso di Fiorano, Roma, Italy. 3 Dipartimento di Biotecnologie Cellulari ed Ematologia, Università di Roma \"La Sapienza\", Roma, Italy. (literal)
Titolo
  • Selective inhibition of miR-92 in hippocampal neurons alters contextual fear memory (literal)
Abstract
  • Post-transcriptional gene regulation mediated by microRNAs (miRNAs) is implicated in memory formation; however, the function of miR-92 in this regulation is uncharacterized. The present study shows that training mice in contextual fear conditioning produces a transient increase in miR-92 levels in the hippocampus and decreases several miR-92 gene targets, including: (i) the neuronal Cl- extruding K+ Cl- co-transporter 2 (KCC2) protein; (ii) the cytoplasmic polyadenylation protein (CPEB3), an RNA-binding protein regulator of protein synthesis in neurons; and (iii) the transcription factor myocyte enhancer factor 2D (MEF2D), one of the MEF2 genes which negatively regulates memory-induced structural plasticity. Selective inhibition of endogenous miR-92 in CA1 hippocampal neurons, by a sponge lentiviral vector expressing multiple sequences imperfectly complementary to mature miR-92 under the control of the neuronal specific synapsin promoter, leads to up-regulation of KCC2, CPEB3 and MEF2D, impairs contextual fear conditioning, and prevents a memory-induced increase in the spine density. Taken together, the results indicate that neuronal-expressed miR-92 is an endogenous fine regulator of contextual fear memory in mice. (literal)
Editore
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Editore di
data.CNR.it