Effects of age-related loss of P/Q-type calcium channels in a mice model of peripheral nerve injury (Articolo in rivista)

Type
Label
  • Effects of age-related loss of P/Q-type calcium channels in a mice model of peripheral nerve injury (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.neurobiolaging.2014.07.025 (literal)
Alternative label
  • Marinelli S.; Eleuteri C.; Vacca V.; Strimpakos G.; Mattei E.; Severini C.; Pavone F.; Luvisetto S. (2014)
    Effects of age-related loss of P/Q-type calcium channels in a mice model of peripheral nerve injury
    in Neurobiology of aging
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Marinelli S.; Eleuteri C.; Vacca V.; Strimpakos G.; Mattei E.; Severini C.; Pavone F.; Luvisetto S. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • 2014.07.25 [Epub ahead of print] (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84906004535&partnerID=q2rCbXpz (literal)
Rivista
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • CNR National Research Council of Italy, Cell Biology and Neurobiology Institute, IRCCS Santa Lucia Foundation, Rome, Italy (literal)
Titolo
  • Effects of age-related loss of P/Q-type calcium channels in a mice model of peripheral nerve injury (literal)
Abstract
  • We analyzed the role of P/Q-type calcium channels in sciatic nerve regeneration after lesion induced by chronic constriction injury (CCI) in heterozygous null mutant mice lacking the CaV2.1?1 subunit of these channels (Cacna1a+/-). Compared with wild type, Cacna1a+/- mice showed an initial reduction of the CCI-induced allodynia, indicating a reduced pain perception, but they also evidenced a lack of recovery over time, with atrophy of the injured hindpaw still present 3 months after CCI when wild-type mice fully recovered. In parallel, Cacna1a+/- mice exhibited an early onset of age-dependent loss of P/Q-type channels, which can be responsible for the lack of functional recovery. Moreover, Cacna1a+/- mice showed an early age-dependent reduction of muscular strength, as well as of Schwann cells proliferation and sciatic nerve remyelination. This study demonstrates the important role played by P/Q-type channels in recovery from nerve injury and has important implications for the knowledge of age-related processes. (literal)
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