Haptoglobin Interacts with Apolipoprotein E and Beta-Amyloid and Influences Their Crosstalk (Articolo in rivista)

Type
Label
  • Haptoglobin Interacts with Apolipoprotein E and Beta-Amyloid and Influences Their Crosstalk (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/cn500099f (literal)
Alternative label
  • Spagnuolo MS, Maresca B, La Marca V, Carrizzo A, Veronesi C, Cupidi C, Piccoli T, Maletta RG, Bruni AC, Abrescia P, Cigliano L (2014)
    Haptoglobin Interacts with Apolipoprotein E and Beta-Amyloid and Influences Their Crosstalk
    in ACS chemical neuroscience
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Spagnuolo MS, Maresca B, La Marca V, Carrizzo A, Veronesi C, Cupidi C, Piccoli T, Maletta RG, Bruni AC, Abrescia P, Cigliano L (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 11 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • PubMed (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Spagnuolo MS--ISPAAM, Consiglio Nazionale delle Ricerche Maresca B, La Marca V, Abrescia P, Cigliano L--I.R.C.C.S Neuromed, Unità di Fisiopatologia VascolareDipartimento di Biologia, Università di Napoli Federico II. Carrizzo A--I.R.C.C.S Neuromed, Unità di Fisiopatologia Vascolare. Veronesi C--Dipartimento di Scienze Biomediche e Chirurgico Specialistiche, Università di Ferrara. Cupidi C, Maletta RG, Bruni AC--Centro Regionale di Neurogenetica, ASP Catanzaro. Piccoli T--Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Università di Palermo (literal)
Titolo
  • Haptoglobin Interacts with Apolipoprotein E and Beta-Amyloid and Influences Their Crosstalk (literal)
Abstract
  • Beta-amyloid accumulation in brain is a driving force for Alzheimer's disease pathogenesis. Apolipoprotein E (ApoE) represents a critical player in beta-amyloid homeostasis, but its role in disease progression is controversial. We previously reported that the acute-phase protein haptoglobin binds ApoE and impairs its function in cholesterol homeostasis. The major aims of this study were to characterize the binding of haptoglobin to beta-amyloid, and to evaluate whether haptoglobin affects ApoE binding to beta-amyloid. Haptoglobin is here reported to form a complex with beta-amyloid as shown by immunoblotting experiments with purified proteins, or by its immunoprecipitation in brain tissues from patients with Alzheimer's disease. The interaction between ApoE and beta-amyloid was previously shown to be crucial for limiting beta-amyloid neurotoxicity and for promoting its clearance. We demonstrate that haptoglobin, rather than impairing ApoE binding to beta-amyloid, promotes to a different extent the formation of the complex between beta-amyloid and ApoE2 or ApoE3 or ApoE4. Our data suggest that haptoglobin and ApoE functions in brain should be evaluated taking into account their mutual interaction with beta-amyloid. Hence, the risk of developing Alzheimer's disease might not only be linked to the different ApoE isoforms, but also rely on the level of critical ligands, such as haptoglobin. (literal)
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