http://www.cnr.it/ontology/cnr/individuo/prodotto/ID283563

Smart magnetic poly(N-isopropylacrylamide) to control the release of bio-active molecules (Articolo in rivista)

Type

Label

Smart magnetic poly(N-isopropylacrylamide) to control the release of bio-active molecules (Articolo in rivista) (literal)

Anno

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

Alternative label

Dionigi, Chiara; Lungaro, Lisa; Goranov, Vitaly A.; Riminucci, Alberto; Piñeiro-Redondo, Yolanda; Bañobre-López, Manuel; Rivas, José Carlos; Dediu, Valentin Alek (2014)
Smart magnetic poly(N-isopropylacrylamide) to control the release of bio-active molecules
in Journal of materials science. Materials in medicine; Chapman and Hall, London (Regno Unito)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Dionigi, Chiara; Lungaro, Lisa; Goranov, Vitaly A.; Riminucci, Alberto; Piñeiro-Redondo, Yolanda; Bañobre-López, Manuel; Rivas, José Carlos; Dediu, Valentin Alek (literal)

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http://www.scopus.com/record/display.url?eid=2-s2.0-84892926133&origin=inward (literal)

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Istituto Per Lo Studio Dei Materiali Nanostrutturati, Rome; Universidad de Santiago de Compostela; International Iberian Nanotechnology Laboratory (literal)

Titolo

Smart magnetic poly(N-isopropylacrylamide) to control the release of bio-active molecules (literal)

Abstract

Thermo switchable magnetic hydrogels undoubtedly have a great potential for medical applications since they can behave as smart carriers able to transport bioactive molecules to a chosen part of the body and release them on demand via magneto-thermal activation. We report on the ability to modify the lower critical solution temperature (LCST) of poly(N-isopropylacrylamide) (PNIPAM) on demand from 32 °C to LCST >=37 °C. This was achieved by the absorption of controlled amounts of magnetite nanoparticles on the polymer chains. We show, through the effect on cell viability, that the resulting magnetic PNIPAM is able to trap and to release bio-active molecules, such as cell growth factors. The activities of the released bio molecule are tested on human umbilical vein endothelial cells culture. We demonstrate that the LCST of the magnetic PNIPAM can be reached remotely via inductive heating with an alternating magnetic field. This approach on magnetic PNIPAM clearly supports appealing applications in safe biomedicine. © 2014 Springer Science+Business Media New York. (literal)

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