Self-Assembly of a Model Peptide Incorporating a Hexa-Histidine Sequence Attached to an Oligo-Alanine Sequence, and binding to Gold NTA/Nickel Nanoparticles (Articolo in rivista)

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  • Self-Assembly of a Model Peptide Incorporating a Hexa-Histidine Sequence Attached to an Oligo-Alanine Sequence, and binding to Gold NTA/Nickel Nanoparticles (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/bm500950c (literal)
Alternative label
  • Hamley, Ian W and Kirkham, Steven and Dehsorkhi, Ashkan and Adamcik, Jozef and Castelletto, Valeria and Mezzenga, Raffaele and Ruokolainen, Janne and Mazzuca, Claudia and Gatto, Emanuela and Venanzi, Mariano and Placidi, Ernesto and Bilalis, Panayiotis and Iatrou, Hermis (2014)
    Self-Assembly of a Model Peptide Incorporating a Hexa-Histidine Sequence Attached to an Oligo-Alanine Sequence, and binding to Gold NTA/Nickel Nanoparticles
    in Biomacromolecules; ACS, American chemical society, Washington, DC (Stati Uniti d'America)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Hamley, Ian W and Kirkham, Steven and Dehsorkhi, Ashkan and Adamcik, Jozef and Castelletto, Valeria and Mezzenga, Raffaele and Ruokolainen, Janne and Mazzuca, Claudia and Gatto, Emanuela and Venanzi, Mariano and Placidi, Ernesto and Bilalis, Panayiotis and Iatrou, Hermis (literal)
Pagina inizio
  • 3412 (literal)
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  • 3420 (literal)
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  • http://pubs.acs.org/doi/abs/10.1021/bm500950c (literal)
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  • 15 (literal)
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  • 9 (literal)
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  • 9 (literal)
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  • ISI Web of Science (WOS) (literal)
  • Google Scholar (literal)
  • Scopus (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dept of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK Food and Soft Materials Science, ETH Zu?rich, Schmelzbergstrasse 9, 8092 Zu?rich, Switzerland Department of Applied Physics, Aalto University School of Science, P.O.Box 15100 FI-00076 Aalto, Finland Department of Chemical Sciences and Technologies, University of Rome \"Tor Vergata\", Via Ricerca Scientifica 1, 00133 Rome, Italy Institute of Structure of Matter, CNR, Department of Physics, University of Rome \"Tor Vergata\", 00133 Rome, Italy University of Athens, Department of Chemistry, Panepistimiopolis Zografou, 157 71 Athens, Greece (literal)
Titolo
  • Self-Assembly of a Model Peptide Incorporating a Hexa-Histidine Sequence Attached to an Oligo-Alanine Sequence, and binding to Gold NTA/Nickel Nanoparticles (literal)
Abstract
  • Amyloid fibrils are formed by a model surfactant-like peptide (Ala)10-(His)6 containing a hexa-histidine tag. This peptide undergoes a remarkable two-step self-assembly process with two distinct critical aggregation concentrations (cacs), probed by fluorescence techniques. A micromolar range cac is ascribed to the formation of pre-fibrillar structures, whereas a millimolar range cac is associated with the formation of well defined but more compact fibrils. We examine the labelling of these model tagged amyloid fibrils using Ni-NTA functionalized gold nanoparticles (Nanogold). Successful labelling is demonstrated via electron microscopy imaging. The specificity of tagging does not disrupt the ?-sheet structure of the peptide fibrils. Binding of fibrils and Nanogold is found to influence the circular dichroism associated with the gold nanoparticle Plasmon absorption band. These results highlight a new approach to the fabrication of functionalized amyloid fibrils and the creation of peptide/ nanoparticle hybrid materials. (literal)
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