http://www.cnr.it/ontology/cnr/individuo/prodotto/ID283052
Peptide-based carbon nanotubes for mitochondrial targeting (Articolo in rivista)
- Type
- Label
- Peptide-based carbon nanotubes for mitochondrial targeting (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1039/c3nr02694a (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Battigelli A.; Russier J.; Venturelli E.; Fabbro C.; Petronilli V.; Bernardi P.; Da Ros T.; Prato M.; Bianco A. (literal)
- Pagina inizio
- Pagina fine
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- http://www.scopus.com/inward/record.url?eid=2-s2.0-84884272360&partnerID=q2rCbXpz (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
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- Note
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- Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, Trieste 34127, Italy; CNRS, Institut de Biologie Moléculaire et Cellulaire, UPR 3572, Strasbourg 67000, France; Department of Molecular Sciences and Nanosystems, Ca' Foscari, University of Venice, Dorsoduro 2137, Venezia 30123, Italy; CNR Institute of Neuroscience, Department of Biomedical Sciences, University of Padova, Viale Giuseppe Colombo 3, Padova 35121, Italy (literal)
- Titolo
- Peptide-based carbon nanotubes for mitochondrial targeting (literal)
- Abstract
- In the present study, we report the design and synthesis of peptide-based-multi-walled carbon nanotubes (MWCNTs) to target mitochondria. Targeting these intracellular organelles might open the way to develop alternative systems to address diseases related to genetic mutations in mitochondrial (mt)-DNA, by delivering therapeutic oligonucleotides. The first step towards mitochondrial delivery of this type of nucleic acid was to target MWCNTs to mitochondria by covalent functionalization with a well-known endogenous mitochondrial targeting sequence (MTS). The subcellular localization of the conjugates, which were fluorescently labeled, in murine RAW 264.7 macrophages and human HeLa cells was then studied using different microscopy techniques, such as wide-field epifluorescence microscopy, confocal laser scanning microscopy (CLSM) and transmission electron microscopy (TEM). The localization of the MTS-MWCNT conjugates into mitochondria was further confirmed by analyzing the isolated organelles using TEM. © The Royal Society of Chemistry 2013. (literal)
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- Autore CNR
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