Heterogeneity of Ca2+ handling among and within Golgi compartments (Articolo in rivista)

Type
Label
  • Heterogeneity of Ca2+ handling among and within Golgi compartments (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1093/jmcb/mjt024 (literal)
Alternative label
  • Wong A.K.C.; Capitanio P.; Lissandron V.; Bortolozzi M.; Pozzan T.; Pizzo P. (2013)
    Heterogeneity of Ca2+ handling among and within Golgi compartments
    in Journal of Molecular Cell Biology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Wong A.K.C.; Capitanio P.; Lissandron V.; Bortolozzi M.; Pozzan T.; Pizzo P. (literal)
Pagina inizio
  • 266 (literal)
Pagina fine
  • 276 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pubmed/23918284 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 5 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 4 (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Biomedical Sciences, University of Padua, 35121 Padua, Italy; Department of Physics, University of Padua, 35121 Padua, Italy; Venetian Institute of Molecular Medicine, 35129 Padua, Italy; Institute of Neuroscience, Italian National Research Council (CNR), Padua Section, 35121 Padua, Italy (literal)
Titolo
  • Heterogeneity of Ca2+ handling among and within Golgi compartments (literal)
Abstract
  • The Golgi apparatus (GA) is a dynamic intracellular Ca21 store endowed with complex Ca21 homeostatic mechanisms in part distinct from those of the endoplasmic reticulum (ER). We describe the generation of a novel fluorescent Ca21 probe selectively targeted to the medialGolgi. We demonstrate that in the medial-Golgi: (i) Ca21 accumulation takes advantage of two distinct pumps, the sarco/endoplasmic reticulum Ca21 ATPase and the secretory pathway Ca21 ATPase1; (ii) activation of IP3 or ryanodine receptors causes Ca21 release, while no functional two-pore channel was found; (iii) luminal Ca21 concentration appears higher than that of the trans-Golgi, but lower than that of the ER, suggesting the existence of a cis- to trans-Golgi Ca21 concentration gradient. Thus, the GA represents a Ca21 store of high complexitywhere,despite the continuousflowofmembranes and luminalcontents, eachsub-compartmentmaintainsits Ca21 identity with specific Ca21 homeostatic characteristics. The functional role of such micro-heterogeneity in GA Ca21 handling is discussed. (literal)
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