http://www.cnr.it/ontology/cnr/individuo/prodotto/ID283042
Calcium channels and migraine (Articolo in rivista)
- Type
- Label
- Calcium channels and migraine (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.bbamem.2012.11.012 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.ncbi.nlm.nih.gov/pubmed/23165010 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Scopu (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Dept. of Biomedical Sciences, University of Padova, V.le G. Colombo 3, 35121 Padova, Italy; CNR Institute of Neuroscience, 35121 Padova, Italy (literal)
- Titolo
- Calcium channels and migraine (literal)
- Abstract
- Missense mutations in CACNA1A, the gene that encodes the pore-forming ?1 subunit of human voltage-gated
CaV2.1 (P/Q-type) calcium channels, cause a rare form of migraine with aura (familial hemiplegic migraine
type 1: FHM1). Migraine is a common disabling brain disorder whose key manifestations are recurrent
attacks of unilateral headache that may be preceded by transient neurological aura symptoms. This review,
first, briefly summarizes current understanding of the pathophysiological mechanisms that are believed to
underlie migraine headache, migraine aura and the onset of a migraine attack, and briefly describes the localization
and function of neuronal CaV2.1 channels in the brain regions that have been implicated in migraine
pathogenesis. Then, the review describes and discusses i) the functional consequences of FHM1 mutations on
the biophysical properties of recombinant human CaV2.1 channels and native CaV2.1 channels in neurons of
knockin mouse models carrying the mild R192Q or severe S218L mutations in the orthologous gene, and
ii) the functional consequences of these mutations on neurophysiological processes in the cerebral cortex
and trigeminovascular system thought to be involved in the pathophysiology of migraine, and the insights
into migraine mechanisms obtained from the functional analysis of these processes in FHM1 knockin mice.
This article is part of a Special Issue entitled: Calcium channels. (literal)
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- Autore CNR
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