Secreted protein kinases? (Articolo in rivista)

Type
Label
  • Secreted protein kinases? (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.tibs.2013.06.006 (literal)
Alternative label
  • Wang S.-K.; Samann A.C.; Simmer J.P. (2013)
    Secreted protein kinases?
    in Trends in biochemical sciences (Regul. ed.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Wang S.-K.; Samann A.C.; Simmer J.P. (literal)
Pagina inizio
  • 424 (literal)
Pagina fine
  • 425 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pubmed/23276407 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 38 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 9 (literal)
Note
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, Ann Arbor, MI 48108, United States (literal)
Titolo
  • Secreted protein kinases? (literal)
Abstract
  • Protein kinases constitute one of the largest gene families and control many aspects of cellular life. In retrospect, the first indication for their existence was reported 130 years ago when the secreted protein, casein, was shown to contain phosphate. Despite its identification as the first phosphoprotein, the responsible kinase has remained obscure. This conundrum was solved with the discovery of a novel family of atypical protein kinases that are secreted and appear to phosphorylate numerous extracellular proteins, including casein. Fam20C, the archetypical member, phosphorylates secreted proteins within Ser-x-Glu/pSer motifs. This discovery has solved a 130-year-old mystery and has shed light on several human disorders of biomineralization. © 2012 Elsevier Ltd. (literal)
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