Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25 (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25 (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.cub.2012.11.026 (literal)

Alternative label

• Marchi S.; Lupini L.; Patergnani S.; Rimessi A.; Missiroli S.; Bonora M.; Bononi A.; Corra F.; Giorgi C.; De Marchi E.; Poletti F.; Gafa R.; Lanza G.; Negrini M.; Rizzuto R.; Pinton P. (2013)
  Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25
  in Current biology
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Marchi S.; Lupini L.; Patergnani S.; Rimessi A.; Missiroli S.; Bonora M.; Bononi A.; Corra F.; Giorgi C.; De Marchi E.; Poletti F.; Gafa R.; Lanza G.; Negrini M.; Rizzuto R.; Pinton P. (literal)

Pagina inizio

• 58 (literal)

Pagina fine

• 63 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/23246404 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 23 (literal)

Rivista

• Current biology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• Scopu (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Morphology, Surgery and Experimental Medicine, Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara, 44121 Ferrara, Italy; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy; Anatomic Pathology Section, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy; Department of Biomedical Sciences, University of Padua, CNR Neuroscience Institute, 35129 Padua, Italy (literal)

Titolo

• Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25 (literal)

Abstract

• The recently discovered mitochondrial calcium uniporter (MCU) promotes Ca2+ accumulation into the mitochondrial matrix [1, 2]. We identified in silico miR-25 as a cancer-related MCU-targeting microRNA family and demonstrate that its overexpression in HeLa cells drastically reduces MCU levels and mitochondrial Ca2+ uptake, while leaving other mitochondrial parameters and cytosolic Ca2+ signals unaffected. In human colon cancers and cancer-derived cells, miR-25 is overexpressed and MCU accordingly silenced. miR-25- dependent reduction of mitochondrial Ca2+ uptake correlates with resistance to apoptotic challenges and can be reversed by anti-miR-25 overexpression. Overall, the data demonstrate that microRNA targeting of mitochondrial Ca2+ signaling favors cancer cell survival, thus providing mechanistic insight into the role of mitochondria in tumorigenesis and identifying a novel therapeutic target in neoplasia. (literal)

Prodotto di

• Biologia e Fisiopatologia Neuromuscolare (ME.P01.005.001) (Modulo)
• Institute of neuroscience (IN) (Istituto)

Incoming links:

Prodotto

• Institute of neuroscience (IN) (Istituto)
• Biologia e Fisiopatologia Neuromuscolare (ME.P01.005.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Current biology (Rivista)

Autore CNR di

• http://www.cnr.it/ontology/cnr/individuo/unitaDiPersonaleEsterno/ID24696