A new Mycobacterium tuberculosis smooth colony reduces growth inside human macrophages and represses PDIM Operon gene expression. Does an heterogeneous population exist in intracellular mycobacteria? (Articolo in rivista)

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  • A new Mycobacterium tuberculosis smooth colony reduces growth inside human macrophages and represses PDIM Operon gene expression. Does an heterogeneous population exist in intracellular mycobacteria? (Articolo in rivista) (literal)
Anno
  • 2012-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.micpath.2012.06.002 (literal)
Alternative label
  • Giovannini, Daniela; Cappelli, Giulia; Jiang, Lina; Castilletti, Concetta; Colone, Alessia; Serafino, Annalucia; Wannenes, Francesca; Giaco, Luciano; Quintiliani, Gianluca; Fraziano, Maurizio; Nepravishta, Ridvan; Colizzi, Vittorio; Mariani, Francesca (2012)
    A new Mycobacterium tuberculosis smooth colony reduces growth inside human macrophages and represses PDIM Operon gene expression. Does an heterogeneous population exist in intracellular mycobacteria?
    in Microbial pathogenesis
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Giovannini, Daniela; Cappelli, Giulia; Jiang, Lina; Castilletti, Concetta; Colone, Alessia; Serafino, Annalucia; Wannenes, Francesca; Giaco, Luciano; Quintiliani, Gianluca; Fraziano, Maurizio; Nepravishta, Ridvan; Colizzi, Vittorio; Mariani, Francesca (literal)
Pagina inizio
  • 135 (literal)
Pagina fine
  • 146 (literal)
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  • 53 (literal)
Rivista
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  • 12 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 3-4 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Natl Res Council IBCN CNR; Natl Res Council IFT CNR; University of Rome Tor Vergata; Jilin University; Natl Inst Infect Dis; University of Rome Tor Vergata (literal)
Titolo
  • A new Mycobacterium tuberculosis smooth colony reduces growth inside human macrophages and represses PDIM Operon gene expression. Does an heterogeneous population exist in intracellular mycobacteria? (literal)
Abstract
  • It was phagocytosed more than wt by MDM, where it grew significantly less, but persisted therein till 14 days infection. It induced significantly less IFN-gamma, IL-12 and IL-27 transcription than wt in infected MDM, while it increased the transcription of inducible NOS. It resided in mature, LAMP-3 positive phagolysosomes, where it never formed cords. This apparently \"weaker\" colony might represent an adaptive intracellular phenotype, whose infection may be less productive, but probably better equipped for a long lasting persistence in mildly activated host cells. (C) 2012 Elsevier Ltd. All rights reserved. (literal)
  • Mycobacterium tuberculosis (MTB) colony morphology was associated to the pathogen's virulence. We isolated a new MTB H37Rv smooth colony, which only appeared following human macrophages (MDM) infection. The new phenotype was Alcohol-Acid resistant, but devoid of a covering capsule and biofilm defective. We ascertained that there were no deletions in the Rv0096-Rv0101 PDIM Operon, but that its expression was repressed as compared to MTB wild type (wt). Its lipid composition displayed lower PDIM components and higher TAG as compared to wt. In MDM it induced the sigma factors sigB, sigI and sigL expression vs. synthetic medium culture, while it repressed other six sigma factors. It also induced, significantly more than wt, mprA, a mycobacterial persistence regulator. (literal)
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