Synthesis, characterization and antimicrobial activity of conjugates based on fluoroquinolon-type antibiotics and gelatin (Articolo in rivista)

Type
Label
  • Synthesis, characterization and antimicrobial activity of conjugates based on fluoroquinolon-type antibiotics and gelatin (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s10856-013-5053-8 (literal)
Alternative label
  • Cirillo G. [ 1,2 ] ; Mauro M.V.[ 3 ] ; Spizzirri U.G. [ 1 ]; Cavalcanti P. [ 3 ]; Puoci F.[ 1 ] ; Giraldi C.[ 3 ] ; Vittorio O.[ 4,5,6,7 ] ; Picci N.[ 1 ]; Iemma F.[ 1 ] (2014)
    Synthesis, characterization and antimicrobial activity of conjugates based on fluoroquinolon-type antibiotics and gelatin
    in Journal of materials science. Materials in medicine (Dordr., Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cirillo G. [ 1,2 ] ; Mauro M.V.[ 3 ] ; Spizzirri U.G. [ 1 ]; Cavalcanti P. [ 3 ]; Puoci F.[ 1 ] ; Giraldi C.[ 3 ] ; Vittorio O.[ 4,5,6,7 ] ; Picci N.[ 1 ]; Iemma F.[ 1 ] (literal)
Pagina inizio
  • 67 (literal)
Pagina fine
  • 77 (literal)
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  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84893385644&partnerID=q2rCbXpz (literal)
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  • 25 (literal)
Rivista
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  • 1 (literal)
Note
  • Scopu (literal)
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  • [ 1 ] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, CS, Italy [ 2 ] Leibniz Inst Solid State & Mat Res Dresden, D-01171 Dresden, Germany [ 3 ] AO SS Annunziata Cosenza, Microbiol & Virol Dept, I-87100 Cosenza, Italy [ 4 ] Scuola Normale Super Pisa, NEST, I-56126 Pisa, Italy [ 5 ] CNR, Ist Nanosci, I-56126 Pisa, Italy [ 6 ] Univ New S Wales, Lowy Canc Res Ctr, Childrens Canc Inst Australia, Sydney, NSW, Australia [ 7 ] Univ New S Wales, Australian Ctr Nanomed, Sydney, NSW, Australia (literal)
Titolo
  • Synthesis, characterization and antimicrobial activity of conjugates based on fluoroquinolon-type antibiotics and gelatin (literal)
Abstract
  • Different fluoroquinolon-type antibiotics were conjugated to gelatin with the aim to synthesize biomacromolecules with antimicrobial properties. The covalent linkage of the antibiotic was performed by a radical process involving the residues in the side chains of gelatin able to undergo oxidative modifications. The conjugation of antibiotic moieties onto the protein structure was confirmed by FT-IR, UV-Vis, fluorescence, and calorimetric analyses. Biocompatibility tests were performed on human bone marrow mesenchymal stromal cells and the antibacterial properties of bioactive polymers were investigated by appropriate tests against Klebsiella pneumoniae and Escherichia coli. With regard to the tests conducted in the presence of E. coli, a minimum inhibitory concentration (MIC) ranging from 0.05 to 0.40 mu g mL(-1) was recorded, while in the presence of K. pneumoniae this concentration varies from 0.10 to 1.60 mu g mL(-1). In all the conjugates, the drug moieties retain their biological activity and the MIC values are lower than the resistance parameters of fluoroquinolon-type antibiotics versus Enterobacteriacae. The collected data suggest a broad range of applications, from biomedical to pharmaceutical and food science for all conjugates. (literal)
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