Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150 (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150 (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1182/blood-2010-12-326629 (literal)

Alternative label

• Ghisi, Margherita; Corradin, Alberto; Basso, Katia; Frasson, Chiara; Serafin, Valentina; Mukherjee, Subhamoy; Mussolin, Lara; Ruggero, Katia; Bonanno, Laura; Guffanti, Alessandro; De Bellis, Gianluca; Gerosa, Gino; Stellin, Giovanni; D'Agostino, Donna M.; Basso, Giuseppe; Bronte, Vincenzo; Indraccolo, Stefano; Amadori, Alberto; Zanovello, Paola (2011)
  Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150
  in Blood
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ghisi, Margherita; Corradin, Alberto; Basso, Katia; Frasson, Chiara; Serafin, Valentina; Mukherjee, Subhamoy; Mussolin, Lara; Ruggero, Katia; Bonanno, Laura; Guffanti, Alessandro; De Bellis, Gianluca; Gerosa, Gino; Stellin, Giovanni; D'Agostino, Donna M.; Basso, Giuseppe; Bronte, Vincenzo; Indraccolo, Stefano; Amadori, Alberto; Zanovello, Paola (literal)

Pagina inizio

• 7053 (literal)

Pagina fine

• 7062 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 117 (literal)

Rivista

• Blood (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 26 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Padua; University of Padua; Columbia University; University of Padua; Consiglio Nazionale delle Ricerche (CNR); University of Padua; Ist Ricovero & Cura Carattere Sci (literal)

Titolo

• Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150 (literal)

Abstract

• Ontogenesis of T cells in the thymus is a complex process whose molecular control is poorly understood. The present study investigated microRNAs involved in human thymocyte differentiation by comparing the microRNA expression profiles of thymocytes at the double-positive, single-positive CD4(+) and single-positive CD8(+) maturation stages. Microarray analysis showed that each thymocyte population displays a distinct microRNA expression profile that reflects their developmental relationships. Moreover, analysis of small-RNA libraries generated from human unsorted and double-positive thymocytes and from mature peripheral CD4(+) and CD8(+) T lymphocytes, together with the microarray data, indicated a trend toward up-regulation of microRNA expression during T-cell maturation after the double-positive stage and revealed a group of microRNAs regulated during normal T-cell development, including miR-150, which is strongly up-regulated as maturation progresses. We showed that miR-150 targets NOTCH3, a member of the Notch receptor family that plays important roles both in T-cell differentiation and leukemogenesis. Forced expression of miR-150 reduces NOTCH3 levels in T-cell lines and has adverse effects on their proliferation and survival. Overall, these findings suggest that control of the Notch pathway through miR-150 may have an important impact on T-cell development and physiology. (Blood. 2011;117(26):7053-7062) (literal)

Autore CNR

• ALESSANDRO GUFFANTI (Unità di personale esterno)
• GIANLUCA DE BELLIS (Unità di personale interno)

Incoming links:

Autore CNR di

• GIANLUCA DE BELLIS (Unità di personale interno)
• ALESSANDRO GUFFANTI (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Blood (Rivista)