http://www.cnr.it/ontology/cnr/individuo/prodotto/ID281151
Antifouling activity of synthetic alkylpyridinium polymers using the barnacle model (Articolo in rivista)
- Type
- Label
- Antifouling activity of synthetic alkylpyridinium polymers using the barnacle model (Articolo in rivista) (literal)
- Anno
- 2014-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.3390/md12041959 (literal)
- Alternative label
Piazza, Veronica; Dragic, Ivanka; Sepcic, Kristina; Faimali, Marco; Garaventa, Francesca; Turk, Tom; Berne, Sabina (2014)
Antifouling activity of synthetic alkylpyridinium polymers using the barnacle model
in Marine drugs
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Piazza, Veronica; Dragic, Ivanka; Sepcic, Kristina; Faimali, Marco; Garaventa, Francesca; Turk, Tom; Berne, Sabina (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
- http://www.mdpi.com/1660-3397/12/4/1959 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- ISMAR-CNR Institute of Marine Science, U.O.S. Genova, Via De Marini 6, 16149 Genova, Italy. veronica.piazza@ge.ismar.cnr.it. (literal)
- Titolo
- Antifouling activity of synthetic alkylpyridinium polymers using the barnacle model (literal)
- Abstract
- Polymeric alkylpyridinium salts (poly-APS) isolated from the Mediterranean marine sponge, Haliclona (Rhizoniera) sarai, effectively inhibit barnacle larva settlement and natural marine biofilm formation through a non-toxic and reversible mechanism. Potential use of poly-APS-like compounds as antifouling agents led to the chemical synthesis of monomeric and oligomeric 3-alkylpyridinium analogues. However, these are less efficient in settlement assays and have greater toxicity than the natural polymers. Recently, a new chemical synthesis method enabled the production of poly-APS analogues with antibacterial, antifungal and anti-acetylcholinesterase activities. The present study examines the antifouling properties and toxicity of six of these synthetic poly-APS using the barnacle (Amphibalanus amphitrite) as a model (cyprids and II stage nauplii larvae) in settlement, acute and sub-acute toxicity assays. Two compounds, APS8 and APS12-3, show antifouling effects very similar to natural poly-APS, with an anti-settlement effective concentration that inhibits 50% of the cyprid population settlement (EC??) after 24 h of 0.32 mg/L and 0.89 mg/L, respectively. The toxicity of APS8 is negligible, while APS12-3 is three-fold more toxic (24-h LC??: nauplii, 11.60 mg/L; cyprids, 61.13 mg/L) than natural poly-APS. This toxicity of APS12-3 towards nauplii is, however, 60-fold and 1200-fold lower than that of the common co-biocides, Zn- and Cu-pyrithione, respectively. Additionally, exposure to APS12-3 for 24 and 48 h inhibits the naupliar swimming ability with respective IC?? of 4.83 and 1.86 mg/L. (literal)
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- Autore CNR
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