Into the redox control: N-acetyl-cysteine pleiotropic effects from the laboratory to clinical applications (Articolo in rivista)

Type
Label
  • Into the redox control: N-acetyl-cysteine pleiotropic effects from the laboratory to clinical applications (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.arthe.2013.11.003 (literal)
Alternative label
  • Parasassi T, Brunelli R, Krasnowska EK, Lundeberg T, PittalugaE, Romano MC (2014)
    Into the redox control: N-acetyl-cysteine pleiotropic effects from the laboratory to clinical applications
    in Acupuncture and related therapies
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Parasassi T, Brunelli R, Krasnowska EK, Lundeberg T, PittalugaE, Romano MC (literal)
Pagina inizio
  • 2 (literal)
Pagina fine
  • 13 (literal)
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  • 2 (literal)
Rivista
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  • Institute of Translational Pharmacology, CNR, Via del Fosso del Cavaliere 100, 00133 Roma, Italy. Department of Gynecologic-Obstetric and Urologic Sciences, Università di Roma Sapienza, Viale del Policlinico 155, 00161 Roma, Italy Foundation for Acupuncture and Alternative Biological Treatment Methods, Sabbatsbergs Hospital, Olivecronas väg 1, 113 24 Stockholm, Sweden Department of Dermatology, Università di Roma Tor Vergata,Viale Oxford 81, 00133 Roma, Italy (literal)
Titolo
  • Into the redox control: N-acetyl-cysteine pleiotropic effects from the laboratory to clinical applications (literal)
Abstract
  • Increasing evidences attribute a central role to oxidation/reduction (redox) homeostasis in controlling cell physiology, with thiol redox transitions of glutathione and sensitive cysteines in protein constituting the major players. Thiol redox control of protein activity and gene expression ultimately extends to the proliferation/differentiation switch. Several diseases, including the highest causes of mortality, have been attributed to a shift towards a more oxidized environment. Interfering with thiol redox transitions in diseases therefore appears a major clinical objective, N-acetyl-cysteine (NAC) being the most obvious candidate drug. Targets comprise diseases related to altered control of proliferation/differentiation, adhesion, inflammation. To quote a few benign disorders, gynecological diseases can include endometriosis, polycystic ovary syndrome, sterility originating from defective embryo implantation; dermatological diseases can include acne, alopecia, psoriasis, and vitiligo. We review here our journey with NAC, from mechanisms identified in cells, though an animal model and finally to the clinic where cases of successful patient's treatment are reported, some unpublished before. NAC effect was eventually enhanced by a combination with melatonin and selenium, both involved in the pathway of redox regulation. Further studies can well extend NAC use to several other diseases, while providing better treatment modalities and helping in identifying further specifically targeted compounds. (literal)
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