http://www.cnr.it/ontology/cnr/individuo/prodotto/ID280708
Modifying bone scaffold architecture in vivo with permanent magnets to facilitate fixation of magnetic scaffolds (Articolo in rivista)
- Type
- Label
- Modifying bone scaffold architecture in vivo with permanent magnets to facilitate fixation of magnetic scaffolds (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.bone.2013.07.015 (literal)
- Alternative label
Panseri S.; Russo A.; Sartori M.; Giavaresi G.; Sandri M.; Fini M.; Maltarello M.C.; Shelyakova T.; Ortolani A.; Visani A.; Dediu V.; Tampieri A.; Marcacci M. (2013)
Modifying bone scaffold architecture in vivo with permanent magnets to facilitate fixation of magnetic scaffolds
in Bone (New York, NY)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Panseri S.; Russo A.; Sartori M.; Giavaresi G.; Sandri M.; Fini M.; Maltarello M.C.; Shelyakova T.; Ortolani A.; Visani A.; Dediu V.; Tampieri A.; Marcacci M. (literal)
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- http://www.scopus.com/inward/record.url?eid=2-s2.0-84881224024&partnerID=q2rCbXpz (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- Note
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- Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute, Bologna, Italy; Laboratory of Musculoskeletal Cell Biology, Rizzoli Orthopaedic Institute, Bologna, Italy; Laboratory of Nano-Biotechnology, Rizzoli Orthopaedic Institute, Bologna, Italy; ISMN - CNR, Institute of Nanostructured Materials - National Research Council, Bologna, Italy; ISTEC - CNR, Institute of Science and Technology for Ceramics, National Research Council, Faenza (RA), Italy; Department of Human Anatomy and Physiopathology of the Locomotor Apparatus, University of Bologna, Bologna, Italy (literal)
- Titolo
- Modifying bone scaffold architecture in vivo with permanent magnets to facilitate fixation of magnetic scaffolds (literal)
- Abstract
- The fundamental elements of tissue regeneration are cells, biochemical signals and the three-dimensional microenvironment. In the described approach, biomineralized-collagen biomaterial functions as a scaffold and provides biochemical stimuli for tissue regeneration. In addition superparamagnetic nanoparticles were used to magnetize the biomaterials with direct nucleation on collagen fibres or impregnation techniques. Minimally invasive surgery was performed on 12 rabbits to implant cylindrical NdFeB magnets in close proximity to magnetic scaffolds within the lateral condyles of the distal femoral epiphyses.Under this static magnetic field we demonstrated, for the first time in vivo, that the ability to modify the scaffold architecture could influence tissue regeneration obtaining a well-ordered tissue. Moreover, the association between NdFeB magnet and magnetic scaffolds represents a potential technique to ensure scaffold fixation avoiding micromotion at the tissue/biomaterial interface. © 2013 Elsevier Inc.. (literal)
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