Atrial Natriuretic Peptide: a Magic Bullet for Cancer Therapy Targeting Wnt Signaling and Cellular pH Regulators (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Atrial Natriuretic Peptide: a Magic Bullet for Cancer Therapy Targeting Wnt Signaling and Cellular pH Regulators (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.2174/0929867321666140205140152 (literal)

Alternative label

• SERAFINO A, Pierimarchi P (2014)
  Atrial Natriuretic Peptide: a Magic Bullet for Cancer Therapy Targeting Wnt Signaling and Cellular pH Regulators
  in Current medicinal chemistry
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• SERAFINO A, Pierimarchi P (literal)

Pagina inizio

• 1 (literal)

Pagina fine

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 21 (literal)

Rivista

• Current medicinal chemistry (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Translational Pharmacology, National Research Council of Italy (literal)

Titolo

• Atrial Natriuretic Peptide: a Magic Bullet for Cancer Therapy Targeting Wnt Signaling and Cellular pH Regulators (literal)

Abstract

• Abstract: Atrial natriuretic peptide (ANP) is a cardiac hormone playing a crucial role in cardiovascular homeostasis mainly through blood volume and pressure regulation. In the last years, the new property ascribed to ANP of inhibiting tumor growth both in vitro and in vivo has made this peptide an attractive candidate for anticancer therapy. The molecular mechanism underlying the anti-proliferative effect of ANP has been mainly related to its interaction with the specific receptors NPRs, through which this natriuretic hormone inhibits some metabolic targets critical for cancer development, including the Ras-MEK1/2-ERK1/2 kinase cascade, functioning as a multikinase inhibitor. In this review we summarize the current knowledge on this topic, focusing on our recent data demonstrating that the antitumor activity of this natriuretic hormone is also mediated by a concomitant effect on the Wnt/?-catenin pathway and on the pH regulation ability of cancer cells, through a Frizzled-related mechanism. This peculiarity of simultaneously targeting two processes crucial for neoplastic transformation and solid tumor survival reinforces the utility of ANP for the development of both preventive and therapeutic strategies (literal)

Prodotto di

• Ricerca traslazionale ed outcome nelle patologie infiammatorie e degenerative (ME.P04.009.001) (Modulo)
• Target molecolari, modelli preclinici ed immunoterapia in Oncologia (ME.P03.015.001) (Modulo)

Autore CNR

• ANNALUCIA SERAFINO (Persona)
• PASQUALE PIERIMARCHI (Unità di personale interno)

Incoming links:

Autore CNR di

• ANNALUCIA SERAFINO (Persona)
• PASQUALE PIERIMARCHI (Unità di personale interno)

Prodotto

• Target molecolari, modelli preclinici ed immunoterapia in Oncologia (ME.P03.015.001) (Modulo)
• Ricerca traslazionale ed outcome nelle patologie infiammatorie e degenerative (ME.P04.009.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Current medicinal chemistry (Rivista)