Characterization of blood redox status of early and mid-late lactating dairy cows (Articolo in rivista)

Type
Label
  • Characterization of blood redox status of early and mid-late lactating dairy cows (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Alternative label
  • L. Cigliano, M. Strazzullo, C. Rossetti, G. Grazioli, G. Auriemma, F. Sarubbi, C. Iannuzzi, L. Iannuzzi, M.S. Spagnuolo (2014)
    Characterization of blood redox status of early and mid-late lactating dairy cows
    in Czech Journal of Animal Science
    (literal)
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  • L. Cigliano, M. Strazzullo, C. Rossetti, G. Grazioli, G. Auriemma, F. Sarubbi, C. Iannuzzi, L. Iannuzzi, M.S. Spagnuolo (literal)
Pagina inizio
  • 170 (literal)
Pagina fine
  • 181 (literal)
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  • Original paper (literal)
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  • 59 (literal)
Rivista
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  • 12 (literal)
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  • 4 (literal)
Note
  • ISI Web of Science (WOS) (literal)
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  • L. Cigliano: Department of Biology, University of Naples Federico II, Naples, Italy. C. Iannuzzi: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy (literal)
Titolo
  • Characterization of blood redox status of early and mid-late lactating dairy cows (literal)
Abstract
  • The effect of the stage of lactation on blood redox homeostasis of bovine and buffalo cows was evaluated. The investigation was carried out on early lactating and mid-late lactating cows, reared in a farm located in Campania (southern Italy). Plasma concentration of ?-tocopherol and ascorbate, the total antioxidant capacity (TAC), glutathione peroxidase (GPx), and superoxide dismutase activities were higher (P < 0.01) in mid-late lactating cows, thus suggesting a higher consumption of antioxidants during early lactation. Plasma concentration of protein-bound carbonyls (PC) and nitrotyrosine (N-Tyr), and the level of lipid hydroperoxides (LPO) were higher (P < 0.01) in early lactating cows, thus suggesting that lipid peroxidation and peroxynitrite production are crucial in determining oxidative modifications in plasma. TAC was positively correlated with ascorbate concentration (P < 0.03), and negatively correlated with PC concentration (P < 0.002), and ascorbate was negatively correlated with PC (P < 0.03) in mid-late lactating group. These findings demonstrate that circulating ascorbate plays a major role in preventing protein modifications induced by carbonyls, and that ascorbate scavenging effect is impaired during early lactation. We calculated a protein oxidative stress index as the ratio (PC + N-Tyr)/TAC multiplied by 100, and we found that this parameter was higher (P < 0.0001) in early lactating cows. Therefore, it could be useful for assessing the extent of protein oxidative damage in relation to the whole antioxidant status. Further, we suggest that the LPO/GPx ratio multiplied by 100 might be used as lipid oxidative stress index in lactating cows. This index was higher (P < 0.0001) in early lactating cows, and might represent a standard parameter for evaluating the lipid damage depending on a deficiency of the enzymatic antioxidant defence. These parameters are proposed for a possible effective description of physiological changes associated with lactation. (literal)
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