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Characterization of blood redox status of early and mid-late lactating dairy cows (Articolo in rivista)
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- Label
- Characterization of blood redox status of early and mid-late lactating dairy cows (Articolo in rivista) (literal)
- Anno
- 2014-01-01T00:00:00+01:00 (literal)
- Alternative label
L. Cigliano, M. Strazzullo, C. Rossetti, G. Grazioli, G. Auriemma, F. Sarubbi, C. Iannuzzi, L. Iannuzzi, M.S. Spagnuolo (2014)
Characterization of blood redox status of early and mid-late lactating dairy cows
in Czech Journal of Animal Science
(literal)
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- L. Cigliano, M. Strazzullo, C. Rossetti, G. Grazioli, G. Auriemma, F. Sarubbi, C. Iannuzzi, L. Iannuzzi, M.S. Spagnuolo (literal)
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- L. Cigliano: Department of Biology, University of Naples Federico II, Naples, Italy.
C. Iannuzzi: Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Naples, Italy (literal)
- Titolo
- Characterization of blood redox status of early and mid-late lactating dairy cows (literal)
- Abstract
- The effect of the stage of lactation on blood redox homeostasis of bovine and buffalo cows was evaluated.
The investigation was carried out on early lactating and mid-late lactating cows, reared in a farm located
in Campania (southern Italy). Plasma concentration of ?-tocopherol and ascorbate, the total antioxidant capacity
(TAC), glutathione peroxidase (GPx), and superoxide dismutase activities were higher (P < 0.01) in mid-late lactating
cows, thus suggesting a higher consumption of antioxidants during early lactation. Plasma concentration of
protein-bound carbonyls (PC) and nitrotyrosine (N-Tyr), and the level of lipid hydroperoxides (LPO) were higher
(P < 0.01) in early lactating cows, thus suggesting that lipid peroxidation and peroxynitrite production are crucial
in determining oxidative modifications in plasma. TAC was positively correlated with ascorbate concentration
(P < 0.03), and negatively correlated with PC concentration (P < 0.002), and ascorbate was negatively correlated
with PC (P < 0.03) in mid-late lactating group. These findings demonstrate that circulating ascorbate plays a major
role in preventing protein modifications induced by carbonyls, and that ascorbate scavenging effect is impaired
during early lactation. We calculated a protein oxidative stress index as the ratio (PC + N-Tyr)/TAC multiplied
by 100, and we found that this parameter was higher (P < 0.0001) in early lactating cows. Therefore, it could be
useful for assessing the extent of protein oxidative damage in relation to the whole antioxidant status. Further,
we suggest that the LPO/GPx ratio multiplied by 100 might be used as lipid oxidative stress index in lactating
cows. This index was higher (P < 0.0001) in early lactating cows, and might represent a standard parameter for
evaluating the lipid damage depending on a deficiency of the enzymatic antioxidant defence. These parameters
are proposed for a possible effective description of physiological changes associated with lactation. (literal)
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