http://www.cnr.it/ontology/cnr/individuo/prodotto/ID279761

Mesenchymal stem cells derived from vertebrae (vMSCs) show best biological properties (Articolo in rivista)

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Mesenchymal stem cells derived from vertebrae (vMSCs) show best biological properties (Articolo in rivista) (literal)

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Brodano G.B.; Terzi S.; Trombi L.; Griffoni C.; Valtieri M.; Boriani S.; Magli M.C. (2013)
Mesenchymal stem cells derived from vertebrae (vMSCs) show best biological properties
in European spine journal (Print)
(literal)

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Brodano G.B.; Terzi S.; Trombi L.; Griffoni C.; Valtieri M.; Boriani S.; Magli M.C. (literal)

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Hematology Division, Department of Oncology, Transplants and New Advances in Medicine, University of Pisa, Pisa, Italy; Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy; Department of Oncological and Degenerative Spine Surgery, Rizzoli Orthopedics Institute, Via G.C. Pupilli, 40136 Bologna, Italy; Institute of Biomedical Technologies, National Research Council (CNR), Pisa, Italy (literal)

Titolo

Mesenchymal stem cells derived from vertebrae (vMSCs) show best biological properties (literal)

Abstract

Purpose Due to their properties and characteristics human mesenchymal stem cells (MSCs) appear to have great therapeutic potential. Many different populations of MSCs have been described and to understand whether they have equivalent biological properties is a critical issue for their therapeutic application. Methods We proposed to analyze the in vitro growth kinetics of MSCs derived from different body sites (iliac crest bone marrow, vertebrae bone marrow, colon mucosa, dental pulp). Results Mesenchymal stem cells derived from vertebrae can be maintained in culture for a greater number of steps and they also generate mature cells of all mesenchymal lineages with greater efficiency, when induced into osteogenic, adipogenic and chondrogenic differentiation. Conclusions The ability of vertebrae-derived MSCs in terms of expansion and differentiation is very interesting at the light of a clinical application for bone fusion in spine surgery. © Springer-Verlag Berlin Heidelberg 2013. (literal)

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