http://www.cnr.it/ontology/cnr/individuo/prodotto/ID279751
A new perylene bisimide bola amphiphile: synthesis, characterization, fluorescent properties and applications as a potential probe (Articolo in rivista)
- Type
- Label
- A new perylene bisimide bola amphiphile: synthesis, characterization, fluorescent properties and applications as a potential probe (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1039/c3nj00116d (literal)
- Alternative label
M. Franceschin, C. Bombelli, S. Borioni, G. Bozzuto, S. Eleuteri, G. Mancini, A. Molinari, A. Bianco (2013)
A new perylene bisimide bola amphiphile: synthesis, characterization, fluorescent properties and applications as a potential probe
in New journal of chemistry (1987); The Royal Society of Chemistry, Cambridge (Regno Unito)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- M. Franceschin, C. Bombelli, S. Borioni, G. Bozzuto, S. Eleuteri, G. Mancini, A. Molinari, A. Bianco (literal)
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- Pagina fine
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- http://pubs.rsc.org (literal)
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- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
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- Scopus (literal)
- ISI Web of Science (WOS) (literal)
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- Sapienza - Universita` di Roma, Dip. Chimica, P.le A. Moro 5, Roma, Italy.
CNR, Istituto di Metodologie Chimiche - Sezione Meccanismi di Reazione and
Dipartimento di Chimica, Sapienza-Universita` di Roma, c/o dipartimento
di Chimica Sapienza-Universita` di Roma, P.le A. Moro 5, Roma, Italy.
Istituto Superiore di Sanita`, Department of Technology and Health, Roma, Italy. (literal)
- Titolo
- A new perylene bisimide bola amphiphile: synthesis, characterization, fluorescent properties and applications as a potential probe (literal)
- Abstract
- Fluorescently-tagged lipids are a powerful tool for investigating the dynamics of lipids in cell biological
studies and in biophysical applications. Herein we report the synthesis and the characterization of a new
bola amphiphile, PC12, based on a bisimidic perylene moiety: a central perylene unit is symmetrically linked
to two aliphatic chains both ending with a quaternary ammonium group. Absorption and fluorescent
properties of the newly synthesized compound were investigated in DMSO and in water as a function of
concentration and temperature. Further, the entrapment efficiency, the fluorescence behavior in dimyristoylsn-
glycero-phosphocholine (DMPC) liposomes, and cell uptake on human and murine glioblastoma cell lines
were evaluated. When loaded in liposomes, PC12 follows the same destiny of liposomes themselves in the
cell cultures: this is an interesting result because PC12 could be used both as an aspecific dye (free form)
and as an organelle-specific lipid probe. (literal)
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