Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.numecd.2014.01.010 (literal)

Alternative label

• 1) Pacifico L, 2) Bonci E, 1) Andreoli G, 1) Romaggioli S, 3) Di Miscio R, 3)Lombardo CV, 4) Chiesa C. (2014)
  Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents
  in NMCD. Nutrition Metabolism and Cardiovascular Diseases (Testo stamp.); Medikal Press, Milano (Italia)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• 1) Pacifico L, 2) Bonci E, 1) Andreoli G, 1) Romaggioli S, 3) Di Miscio R, 3)Lombardo CV, 4) Chiesa C. (literal)

Pagina inizio

• 737 (literal)

Pagina fine

• 743 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni

• Published ahead of print on January 29,2014 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 24 (literal)

Rivista

• NMCD. Nutrition Metabolism and Cardiovascular Diseases (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 7 (literal)

Note

• ubMe (literal)
• ISI Web of Science (WOS) (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1)Department of Pediatrics and Child Neuropsychiatry, Sapienza University of Rome, Italy 2)Department of Experimental Medicine, Sapienza University of Rome, Italy 3)Department of Radiological Sciences, Sapienza University of Rome, Italy 4) Institute of Translational Pharmacology, National Research Council, Rome, Italy (literal)

Titolo

• Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents (literal)

Abstract

• Abstract Background and aims: The triglyceride (TG)/high-density lipoprotein-cholesterol (HDL-C) ratio has been reported as a useful marker of atherogenic lipid abnormalities, insulin resistance, and cardiovascular disease. We evaluated in a large sample of children and adolescents the association of TG/HDL-C ratio with early signs of morphological vascular changes and cardiometabolic risk factors including nonalcoholic fatty liver disease (NAFLD). Methods and results: The study population, including 548 children (aged 6e16 years), of whom 157 were normal-weight, 118 overweight, and 273 obese, had anthropometric, laboratory, liver and carotid ultrasonography (carotid artery intima-media thickness-cIMT) data collected. Subjects were stratified into tertiles of TG/HDL-C. There was a progressive increase in body mass index (BMI), BMI-SD score (SDS), waist circumference, blood pressure (BP), liver enzymes, glucose, insulin, homeostasis model assessment of insulin resistance, high-sensitivity C-reactive protein (hsCRP), and cIMT values across TG/HDL-C tertiles. The odds ratios for central obesity, insulin resistance, high hsCRP, NAFLD, metabolic syndrome, and elevated cIMT increased significantly with the increasing tertile of TG/HDL-C ratio, after adjustment for age, gender, pubertal status, and BMI-SDS. In a stepwise multivariate logistic regression analysis, increased cIMT was associated with high TG/HDL-C ratio [OR, 1.81 (95% CI, 1.08e3.04); P < 0.05], elevated BP [5.13 (95% CI, 1.03e15.08); P < 0.05], insulin resistance [2.16 (95% CI, 1.30e3.39); P < 0.01], and NAFLD [2.70 (95% CI, 1.62e4.56); P < 0.01]. Conclusion: TG/HDL-C ratio may help identify children and adolescents at high risk for structural vascular changes and metabolic derangement. (literal)

Editore

• Medikal Press (Editore)

Prodotto di

• Ricerca traslazionale ed outcome nelle patologie infiammatorie e degenerative (ME.P04.009.001) (Modulo)

Autore CNR

• CLAUDIO CHIESA (Unità di personale interno)
• Lucia Pacifico (Unità di personale esterno)

Insieme di parole chiave

• Keywords of "Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• CLAUDIO CHIESA (Unità di personale interno)
• Lucia Pacifico (Unità di personale esterno)

Prodotto

• Ricerca traslazionale ed outcome nelle patologie infiammatorie e degenerative (ME.P04.009.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• NMCD. Nutrition Metabolism and Cardiovascular Diseases (Rivista)

Editore di

• Medikal Press (Editore)

Insieme di parole chiave di

• Keywords of "Association of serum triglyceride-to-HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents" (Insieme di parole chiave)