http://www.cnr.it/ontology/cnr/individuo/prodotto/ID27861
Chemical-physical properties and in vitro cell culturing of a novel biphasic bio-mimetic scaffold for osteo-chondral tissue regeneration. (Articolo in rivista)
- Type
- Label
- Chemical-physical properties and in vitro cell culturing of a novel biphasic bio-mimetic scaffold for osteo-chondral tissue regeneration. (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Alternative label
Grigolo B, Fiorini M, Manferdini C, Cavallo C, Gabusi E, Zini N, Dolcini L, Nicoletti A, Pressato D, Facchini A, Lisignoli G. (2011)
Chemical-physical properties and in vitro cell culturing of a novel biphasic bio-mimetic scaffold for osteo-chondral tissue regeneration.
in Journal of Biological Regulators & Homeostatic Agents (Testo stamp.)
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- Grigolo B, Fiorini M, Manferdini C, Cavallo C, Gabusi E, Zini N, Dolcini L, Nicoletti A, Pressato D, Facchini A, Lisignoli G. (literal)
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- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Istituto Ortopedico Rizzoli, Bologna, Italy; Laboratorio RAMSES, Istituto Ortopedico Rizzoli, Bologna, Italy; Fin-Ceramica Faenza S.p.A., Faenza (RA), Italy; IGM-CNR, Sezione di Bologna c/o Istituto Ortopedico Rizzoli, Bologna, Italy; Dipartimento di Medicina Interna e Gastroenterologia, Università degli Studi di Bologna, Bologna, Italy (literal)
- Titolo
- Chemical-physical properties and in vitro cell culturing of a novel biphasic bio-mimetic scaffold for osteo-chondral tissue regeneration. (literal)
- Abstract
- The requirements for a successful regeneration of an osteo-chondral defect could effectively be met by using a bi-layered composite scaffold, able to support proliferation and differentiation of mesenchymal stem cells, while providing a biochemical environment promoting the formations of the two distinct tissues. The novel strategy here presented consists of developing a bio-mimetic scaffolds obtained by the combination of two integrated organic compounds (type I collagen and chitosan) with or without bioactive Mg-doped hydroxyapatite (Mg-HA) nanocrystals, depending on the specific layer, reproducing cartilaginous or subchondral bone tissue. An innovative patented methodology for scaffolds production, called - pH-dependent 3-phasic assembling -, allowed to development of a highly homogenous and chemically stable scaffold, presenting a very good integration among all three components, as confirmed by extensive SEM and thermogravimetric analyses. A preliminary in vitro evaluation was also carried out by seeding bi-layered scaffold with human bone marrow stromal cells (h-MSCs), by giving particular emphasis to cell viability and distribution at day 0, 7 and 14. Cells were viable and uniformly colonized the whole scaffold until day 14, indicating that the scaffold contributed to the maintenance of cell behaviour. (literal)
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