Effect of UVA-activated Riboflavin on Dentin Bonding. (Articolo in rivista)

Type
Label
  • Effect of UVA-activated Riboflavin on Dentin Bonding. (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • Cova A, Breschi L, Nato F, Ruggeri A Jr, Carrilho M, Tjäderhane L, Prati C, Di Lenarda R, Tay FR, Pashley DH, Mazzoni A. (2011)
    Effect of UVA-activated Riboflavin on Dentin Bonding.
    in Journal of dental research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cova A, Breschi L, Nato F, Ruggeri A Jr, Carrilho M, Tjäderhane L, Prati C, Di Lenarda R, Tay FR, Pashley DH, Mazzoni A. (literal)
Pagina inizio
  • 1439 (literal)
Pagina fine
  • 1445 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 90 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of SAU&FAL, University of Bologna, Via Irnerio, 48, 40100 Bologna, Italy; Department of Medical Sciences, Unit of Dental Sciences and Biomaterials, University of Trieste, Trieste, Italy; IGM, Unit of Bologna, C.N.R.-IOR, Bologna, Italy; Department of STeVA, University “Carlo Bo”, Urbino, Italy; Biomaterials Research Group, Bandeirante University of Sao Paulo – UNIBAN, Brazil; Institute of Dentistry, University of Oulu, Oulu University Hospital, Oulu, Finland; Department of Dental Sciences, University of Bologna, Bologna, Italy; Department of Endodontics, College of Dental Medicine, Georgia Health Sciences University, Augusta, GA, USA; Department of Oral Biology, College of Dental Medicine, Georgia Health Sciences University, Augusta, GA, USA; Laboratory of Cell Biology & Laboratory of Immunorheumatology and Tissue Regeneration– Ramses Laboratory, c/o Rizzoli Orthopedic Institute, Bologna, Italy; (literal)
Titolo
  • Effect of UVA-activated Riboflavin on Dentin Bonding. (literal)
Abstract
  • Recent studies have reported collagen cross-linking after exposure to riboflavin followed by ultraviolet-A (UVA) exposure. This study is the first to investigate the effect of a riboflavin-containing primer on adhesive interface stability and dentinal matrix metalloproteinase activity. Human dentin was etched with 35% phosphoric acid, treated with 0.1% riboflavin, exposed to UVA for 2 min, and bonded with a two-step etch-and-rinse adhesive. Adhesive was applied to control specimens without riboflavin/UVA. Specimens were subjected to microtensile bond strength tests and pulled to failure after storage for 24 hrs, 6 mos, or 1 yr. Interfacial nanoleakage was evaluated by light and transmission electron microscopy. To investigate dentinal matrix metalloproteinase activity, we performed correlative zymographic assays on protein extracts obtained from phosphoric-acid-etched dentin powder with or without riboflavin/UVA treatment and XP Bond. Ultraviolet-activated riboflavin treatment increased the immediate bond strength to dentin at all aging intervals (p < 0.05 vs. control) and decreased interfacial nanoleakage in aged specimens (1 yr; p < 0.05). Zymograms revealed that riboflavin/UVA pre-treatment inhibited dentinal matrix metalloproteinase activity (especially MMP-9). In conclusion, dentinal collagen cross-linking induced by riboflavin/UVA increased immediate bond strength, stabilized the adhesive interface, and inhibited dentin matrix metalloproteinases, thereby increasing the durability of resin-dentin bonds. (literal)
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