Neuroprotective effects of donepezil against cholinergic depletion (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Neuroprotective effects of donepezil against cholinergic depletion (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1186/alzrt215 (literal)

Alternative label

• Cutuli Debora 1, 2; De Bartolo Paola 1,2; Caporali Paola 1,2; Tartaglione Anna Maria 1,2; Oddi Diego 1,3; D'Amato Francesca Romana 1,3; Nobili Annalisa 1; D'Amelio Marcello 1,4; Laura Petrosini 1,2 (2013)
  Neuroprotective effects of donepezil against cholinergic depletion
  in Alzheimer's research & therapy
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cutuli Debora 1, 2; De Bartolo Paola 1,2; Caporali Paola 1,2; Tartaglione Anna Maria 1,2; Oddi Diego 1,3; D'Amato Francesca Romana 1,3; Nobili Annalisa 1; D'Amelio Marcello 1,4; Laura Petrosini 1,2 (literal)

Pagina inizio

• 50 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• Alzheimer's research & therapy (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1 IRCCS Fondazione Santa Lucia, Via del Fosso di Fiorano 64, Rome 00143, Italy. 2 Department of Psychology, University of Rome \"Sapienza\", Via dei Marsi 78, Rome 00185, Italy. 3 Cell Biology and Neurobiology Institute, National Research Council, Via del Fosso di Fiorano 64, Rome 00143, Italy. 4 Medical School, Campus Bio-Medico University Molecular Neuroscience Unit, Via Alvaro del Portillo 21, Rome 00128, Italy. (literal)

Titolo

• Neuroprotective effects of donepezil against cholinergic depletion (literal)

Abstract

• Introduction Intraparenchymal injections of the immunotoxin 192-IgG-saporin into medial septum and nucleus basalis magnocellularis causes a selective depletion of basal forebrain cholinergic neurons. Thus, it represents a valid model to mimic a key component of the cognitive deficits associated with aging and dementia. Here we administered donepezil, a potent acetylcholinesterase inhibitor developed for treating Alzheimer's disease, 15 days before 192-IgG-saporin injection, and thus we examined donepezil effects on neurodegeneration and cognitive deficits. Methods Caspase-3 activity and cognitive performances of lesioned rats pre-treated with donepezil or saline were analyzed and compared to the outcomes obtained in pre-treated sham-lesioned rats. Results Cholinergic depletion increased hippocampal and neocortical caspase-3 activity and impaired working memory, spatial discrimination, social novelty preference, and ultrasonic vocalizations, without affecting anxiety levels and fear conditioning. In lesioned animals, donepezil pre-treatment reduced hippocampal and neocortical caspase-3 activity and improved working memory and spatial discrimination performances and partially rescued ultrasonic vocalizations, without preventing social novelty alterations. Conclusions Present data indicate that donepezil pre-treatment exerts beneficial effects on behavioral deficits induced by cholinergic depletion, attenuating the concomitant hippocampal and neocortical neurodegeneration. (literal)

Prodotto di

• ex SV.P16.003.001 / Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.004) (Modulo)

Autore CNR

• FRANCESCA ROMANA D'AMATO (Unità di personale interno)
• DIEGO ODDI (Unità di personale esterno)

Incoming links:

Autore CNR di

• FRANCESCA ROMANA D'AMATO (Unità di personale interno)
• DIEGO ODDI (Unità di personale esterno)

Prodotto

• ex SV.P16.003.001 / Modelli animali di deficit neurocomportamentale: meccanismi di adattamento a stress - modelli animali (SV.P16.003.004) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Alzheimer's research & therapy (Rivista)