Nuclear phosphoinositides and their roles in cell biology and disease. (Articolo in rivista)

Type
Label
  • Nuclear phosphoinositides and their roles in cell biology and disease. (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • Martelli AM, Ognibene A, Buontempo F, Fini M, Bressanin D, Goto K, McCubrey JA, Cocco L, Evangelisti C. (2011)
    Nuclear phosphoinositides and their roles in cell biology and disease.
    in Critical reviews in biochemistry and molecular biology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Martelli AM, Ognibene A, Buontempo F, Fini M, Bressanin D, Goto K, McCubrey JA, Cocco L, Evangelisti C. (literal)
Pagina inizio
  • 436 (literal)
Pagina fine
  • 457 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 46 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Human Anatomy, University of Bologna, Bologna, Italy, Institute of Molecular Genetics, NationalResearch Council, Sezione di Bologna, c/o Rizzoli Orthopedic Institute, Bologna, Italy, Muscoloskeletal Cell Biology Laboratory, and 4Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Bologna, Italy, Department of Anatomy and Cell Biology, Yamagata University School of Medicine, Yamagata, Japan, Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, North Carolina, USA (literal)
Titolo
  • Nuclear phosphoinositides and their roles in cell biology and disease. (literal)
Abstract
  • Since the late 1980s, a growing body of evidence has documented that phosphoinositides and their metabolizing enzymes, which regulate a large variety of cellular functions both in the cytoplasm and at the plasma membrane, are present also within the nucleus, where they are involved in processes such as cell proliferation, differentiation, and survival. Remarkably, nuclear phosphoinositide metabolism operates independently from that present elsewhere in the cell. Although nuclear phosphoinositides generate second messengers such as diacylglycerol and inositol 1,4,5 trisphosphate, it is becoming increasingly clear that they may act by themselves to influence chromatin structure, gene expression, DNA repair, and mRNA export. The understanding of the biological roles played by phosphoinositides is supported by the recent acquisitions demonstrating the presence in the nuclear compartment of several proteins harboring phosphoinositide-binding domains. Some of these proteins have functional roles in RNA splicing/processing and chromatin assembly. Moreover, recent evidence shows that nuclear phospholipase C²1 (a key phosphoinositide metabolizing enzyme) could somehow be involved in the myelodysplastic syndrome, i.e. a hematopoietic disorder that frequently evolves into an acute leukemia. This review aims to highlight the most significant and updated findings about phosphoinositide metabolism in the nucleus under both physiological and pathological conditions. (literal)
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