The Inhibitory Effects of Quaternary Ammonium Methacrylates on Soluble and Matrix-bound MMPs (Articolo in rivista)

Type
Label
  • The Inhibitory Effects of Quaternary Ammonium Methacrylates on Soluble and Matrix-bound MMPs (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • Tezvergil-Mutluay A, Agee KA, Uchiyama T, Imazato S, Mutluay MM, Cadenaro M, Breschi L, Nishitani Y, Tay FR, Pashley DH. (2011)
    The Inhibitory Effects of Quaternary Ammonium Methacrylates on Soluble and Matrix-bound MMPs
    in Journal of dental research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Tezvergil-Mutluay A, Agee KA, Uchiyama T, Imazato S, Mutluay MM, Cadenaro M, Breschi L, Nishitani Y, Tay FR, Pashley DH. (literal)
Pagina inizio
  • 535 (literal)
Pagina fine
  • 540 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 90 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Prosthodontics and Turku Clinical Biomaterials Center, University of Turku, Institute of Dentistry, Lemminkaisenkatu 2, FI-20520, Turku, Finland; School of Dentistry, Medical College of Georgia, Augusta, GA, USA; Department of Renascent Dentistry, Nihon University School of Dentistry at Matsudo, Chiba, Japan; Department of Biomaterial Science, Osaka University Graduate School of Dentistry, Osaka, Japan; Department of Biomedicine, Unit of Dental Sciences and Biomaterials, University of Trieste, Italy; Department of Biomedicine, University of Trieste, Trieste, Italy; IGM-CNR, Unit of Bologna c/o IOR, Bologna, Italy; Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; Department of Endodontics, School of Dentistry, Medical College of Georgia, Augusta, GA, USA. (literal)
Titolo
  • The Inhibitory Effects of Quaternary Ammonium Methacrylates on Soluble and Matrix-bound MMPs (literal)
Abstract
  • Matrix metalloproteinases (MMPs) bound to dentin contribute to the progressive degradation of collagen fibrils in hybrid layers created by dentin adhesives. This study evaluated the MMP-inhibiting potential of quaternary ammonium methacrylates (QAMs), with soluble rhMMP-9 and a matrix-bound endogenous MMP model. Six different QAMs were initially screened by a rhMMP-9 colorimetric assay. For the matrix-bound endogenous MMPs, we aged demineralized dentin beams for 30 days in calcium- and zinc-containing media (CM; control), chlorhexidine, or QAMs in CM to determine the changes in dry mass loss and solubilization of collagen peptides against baseline levels. The inhibitory effects of QAMs on soluble rhMMP-9 varied between 34 and 100%. Beams incubated in CM showed a 29% decrease in dry mass (p < 0.05), whereas beams incubated with QAMs showed only 0.2%-6% loss of dry mass. Significantly more solubilized collagen was detected from beams incubated in CM (p < 0.05). It is concluded that QAMs exhibited dentin MMP inhibition comparable with that of chlorhexidine, but required higher concentrations. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it