Cell Death Forms and HSP70 Expression in U87 Cells after Ionizing Radiation and/or Chemotherapy. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Cell Death Forms and HSP70 Expression in U87 Cells after Ionizing Radiation and/or Chemotherapy. (Articolo in rivista) (literal)

Anno

• 2011-01-01T00:00:00+01:00 (literal)

Alternative label

• Paolini A, Pasi F, Facoetti A, Mazzini G, Corbella F, DI Liberto R, Nano R. (2011)
  Cell Death Forms and HSP70 Expression in U87 Cells after Ionizing Radiation and/or Chemotherapy.
  in Anticancer research
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Paolini A, Pasi F, Facoetti A, Mazzini G, Corbella F, DI Liberto R, Nano R. (literal)

Pagina inizio

• 3727 (literal)

Pagina fine

• 3731 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 31 (literal)

Rivista

• Anticancer research (Rivista)

Note

• ISI Web of Science (WOS) (literal)

Titolo

• Cell Death Forms and HSP70 Expression in U87 Cells after Ionizing Radiation and/or Chemotherapy. (literal)

Abstract

• BACKGROUND: Several types of cell death can induce the activation of the immune system by releasing factors of damage. Aim: To identify different cell death modalities using U87 glioblastoma cell line after radio-chemotherapy treatments by analyzing the expression of HSP70 after ³-ray irradiation and temozolomide treatment. MATERIALS AND METHODS: U87 cell line was irradiated with 2, 4, 8, 10 and 20 Gy, treated with 200 ¼M of temozolomide, or subjected to combined treatments of these. RESULTS: Forty-eight hours after treatment, apoptosis was more prevalent than necrosis, especially after ³-radiation with a somewhat dose-dependent trend. Temozolomide did not seem to induce significant modifications of the pattern of cell death and protein expression. Temozolomide-induced cell death was lower or equal to that obtained with high dose radiotherapy. A low synergism between the two treatments was observed. CONCLUSION: This cell line showed a marked radioresistance to conventional clinical doses, showing attempts to repair the induced damage, while temozolomide treatment showed no cytotoxic effects. (literal)

Prodotto di

• Institute of molecular genetics (IGM) (Istituto)
• Sviluppi metodologici in citometria e applicazioni alla sperimentazione biomedica; in vitro imaging (ME.P06.010.001) (Modulo)

Autore CNR

• GIULIANO MAZZINI (Persona)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Sviluppi metodologici in citometria e applicazioni alla sperimentazione biomedica; in vitro imaging (ME.P06.010.001) (Modulo)

Autore CNR di

• GIULIANO MAZZINI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Anticancer research (Rivista)