Cell Death Forms and HSP70 Expression in U87 Cells after Ionizing Radiation and/or Chemotherapy. (Articolo in rivista)

Type
Label
  • Cell Death Forms and HSP70 Expression in U87 Cells after Ionizing Radiation and/or Chemotherapy. (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • Paolini A, Pasi F, Facoetti A, Mazzini G, Corbella F, DI Liberto R, Nano R. (2011)
    Cell Death Forms and HSP70 Expression in U87 Cells after Ionizing Radiation and/or Chemotherapy.
    in Anticancer research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Paolini A, Pasi F, Facoetti A, Mazzini G, Corbella F, DI Liberto R, Nano R. (literal)
Pagina inizio
  • 3727 (literal)
Pagina fine
  • 3731 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 31 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Titolo
  • Cell Death Forms and HSP70 Expression in U87 Cells after Ionizing Radiation and/or Chemotherapy. (literal)
Abstract
  • BACKGROUND: Several types of cell death can induce the activation of the immune system by releasing factors of damage. Aim: To identify different cell death modalities using U87 glioblastoma cell line after radio-chemotherapy treatments by analyzing the expression of HSP70 after ³-ray irradiation and temozolomide treatment. MATERIALS AND METHODS: U87 cell line was irradiated with 2, 4, 8, 10 and 20 Gy, treated with 200 ¼M of temozolomide, or subjected to combined treatments of these. RESULTS: Forty-eight hours after treatment, apoptosis was more prevalent than necrosis, especially after ³-radiation with a somewhat dose-dependent trend. Temozolomide did not seem to induce significant modifications of the pattern of cell death and protein expression. Temozolomide-induced cell death was lower or equal to that obtained with high dose radiotherapy. A low synergism between the two treatments was observed. CONCLUSION: This cell line showed a marked radioresistance to conventional clinical doses, showing attempts to repair the induced damage, while temozolomide treatment showed no cytotoxic effects. (literal)
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