http://www.cnr.it/ontology/cnr/individuo/prodotto/ID27807
Extracellular calcium chronically-induced human osteoblasts effects: Specific modulation of osteocalcin and collagen type XV. (Articolo in rivista)
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- Label
- Extracellular calcium chronically-induced human osteoblasts effects: Specific modulation of osteocalcin and collagen type XV. (Articolo in rivista) (literal)
- Anno
- 2012-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/jcp.24001 (literal)
- Alternative label
Gabusi E, Manferdini C, Grassi F, Piacentini A, Cattini L, Filardo G, Lambertini E, Piva R, Zini N, Facchini A, Lisignoli G. (2012)
Extracellular calcium chronically-induced human osteoblasts effects: Specific modulation of osteocalcin and collagen type XV.
in Journal of cellular physiology (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Gabusi E, Manferdini C, Grassi F, Piacentini A, Cattini L, Filardo G, Lambertini E, Piva R, Zini N, Facchini A, Lisignoli G. (literal)
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- http://onlinelibrary.wiley.com/doi/10.1002/jcp.24001/abstract (literal)
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- ISI Web of Science (WOS) (literal)
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- Laboratorio RAMSES, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy; Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy; SC Clinica Ortopedica e Traumatologica III, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy; Dipartimento di Biochimica e Biologia Molecolare, Sezione di Biologia Molecolare, Università degli Studi di Ferrara, 44100 Ferrara, Italy; IGM CNR, Sezione di Bologna c/o Istituto Ortopedico Rizzoli, 40136 Bologna, Italy; Dipartimento di Medicina Interna e Gastroenterologia, Università degli Studi di Bologna, 40138 Bologna, Italy (literal)
- Titolo
- Extracellular calcium chronically-induced human osteoblasts effects: Specific modulation of osteocalcin and collagen type XV. (literal)
- Abstract
- Fluctuation in extracellular calcium (Ca2+) concentration occurs during bone remodeling. Free ionised Ca2+ plays a critical role in regulating osteoblast functions. We analyzed the effects of different concentrations of free ionised Ca2+ (0.5, 1.3, 2.6 mM) on human osteoblasts and we evaluated osteoblastic phenotype (marker expression and cell morphology) and functions (osteogenic differentiation, cell proliferation and cell signaling). Our data show human osteoblasts that chronically-stimulated with 0.5, 1.3, or 2.6 mM Ca2+ significantly increase intracellular content of alkaline phosphatase, collagen type I, osteocalcin and bone sialoprotein, whereas collagen type XV was down-modulated and RUNX2 expression was not affected. We also found a Ca2+ concentration-dependent increase in osteogenic differentiation and cell proliferation, associated to an increase of signaling protein PLC²1 and p-ERK. Human osteoblast morphology was affected by Ca2+ as seen by the presence of numerous nucleoli, cells in mitosis, cell junctions and an increased number of vacuoles.
In conclusion, our data show a clear phenotypical and functional effect of extracellular Ca2+ on human osteoblasts and support the hypothesis of a direct role of this cation in the bone remodeling processes. J. Cell. Physiol. © 2011 Wiley Periodicals, Inc. (literal)
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