http://www.cnr.it/ontology/cnr/individuo/prodotto/ID27776
Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice (Articolo in rivista)
- Type
- Label
- Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1038/embor.2010.64 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Lleres D; Denegri M; Biggiogera M; Ajuh P; Lamond AI; (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Dipartimento di Biologia Animale e Istituto di Genetica Molecolare del CNR Pavia (literal)
- Titolo
- Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice (literal)
- Abstract
- Heterogeneous nuclear ribonucleoprotein-M (hnRNP-M) is an abundant nuclear protein that binds to pre-mRNA and is a component of the spliceosome complex. A direct interaction was detected in vivo between hnRNP-M and the human spliceosome proteins cell division cycle 5-like (CDC5L) and pleiotropic regulator 1 (PLRG1) that was inhibited during the heat-shock stress response. A central region in hnRNP-M is required for interaction with CDC5L/PLRG1. hnRNP-M affects both 50 and 30 alternative splice site choices, and an hnRNP-M mutant lacking the CDC5L/PLRG1 interaction domain is unable to modulate alternative splicing of an adeno-E1A mini-gene substrate. (literal)
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