p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1 (Articolo in rivista)

Type
Label
  • p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1 (Articolo in rivista) (literal)
Anno
  • 2005-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.4161/cc.4.9.1978 (literal)
Alternative label
  • Salvioli S; Bonafe' M; Barbi C; Storci G; Trapassi C; Tocco F; Gravina S; Rossi M; Tiberi L; Mondello C; Monti D; Franceschi C. (2005)
    p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1
    in Cell cycle (Georget. Tex.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Salvioli S; Bonafe' M; Barbi C; Storci G; Trapassi C; Tocco F; Gravina S; Rossi M; Tiberi L; Mondello C; Monti D; Franceschi C. (literal)
Pagina inizio
  • 1264 (literal)
Pagina fine
  • 1271 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 4 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 8 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 9 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • In questo lavoro è stato dimostrato che il polimorfismo al codone 72 di p53 influenza la suscettibilità all’induzione di apoptosi e senescenza cellulare in individui anziani. Questa osservazione può contribuire a spiegare la variabilità inter-individuale nella risposta a i farmaci. (literal)
Note
  • PubMe (literal)
  • Scopu (literal)
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Mondello C: Istituto di Genetica Molecolare,CNR, Pavia; Salvioli S, Bonafe' M, Barbi C, Storci G, Trapassi C, Tocco F, Gravina S, Rossi M, Tiberi L: Dip. Patologia Sperimentale, Un. Bologna, Bologna; Monti D: Dip. Patologia Sperimentale e Oncologia, Un. Firenza, Firenze; Franceschi C: Dip. di Patologia Sperimentale, Un. Bologna, Bologna e Dip. Scienze Gerontologiche, I.N.R.C.A., Ancona; (literal)
Titolo
  • p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1 (literal)
Abstract
  • A common polymorphism at codon 72 in p53 gene leads to an arginine to proline aminoacidic substitution which affects in an age-dependent manner the susceptibility of cells to undergo apoptosis after oxidative stress. Here we report that dermal fibroblasts from Proline allele carriers (Pro+) display a higher expression of p21WAF1 gene, in both basal conditions and after treatment with doxorubicin and camptothecin. This phenomenon is accompanied by a lower susceptibility of Pro+ cells to undergo apoptosis, a lower capability to over cross G1-S transition and an increased propensity to express markers of cell senescence, with respect to fibroblasts from Arginine homozygotes (Pro-). All these phenomena are particularly evident in cells from centenarians. We conclude that the functional difference between the two p53 codon 72 alleles exerts a broad impact on the capability of cell from aged people to respond to stressors such as cytotoxic drugs. (literal)
Prodotto di
Autore CNR
Insieme di parole chiave

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
Insieme di parole chiave di
data.CNR.it