Mineralization behaviour with mesenchymal stromal cells in a biomimetic hyaluronic acid-based scaffold (Articolo in rivista)

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Label
  • Mineralization behaviour with mesenchymal stromal cells in a biomimetic hyaluronic acid-based scaffold (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.biomaterials.2010.01.148 (literal)
Alternative label
  • Cristina Manferdini; Vincenzo Guarino; Nicoletta Zini; Maria Grazia Raucci; Andrea Ferrari; Francesco Grassi; Elena Gabusi; Stefano Squarzoni; Andrea Facchini; Luigi Ambrosio (2010)
    Mineralization behaviour with mesenchymal stromal cells in a biomimetic hyaluronic acid-based scaffold
    in Biomaterials
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cristina Manferdini; Vincenzo Guarino; Nicoletta Zini; Maria Grazia Raucci; Andrea Ferrari; Francesco Grassi; Elena Gabusi; Stefano Squarzoni; Andrea Facchini; Luigi Ambrosio (literal)
Pagina inizio
  • 3986 (literal)
Pagina fine
  • 3996 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 31 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, Bologna 40136, Italy; Institute of Composite and Biomedical Materials, National Research Council, Naples, Italy; IGM-CNR, Sezione di Bologna c/o Istituto Ortopedico Rizzoli, Bologna 40136, Italy; SC Laboratorio Biologia Cellulare Muscoloscheletrica, Istituto Ortopedico Rizzoli, Bologna 40136, Italy; Dipartimento di Medicina Interna e Gastroenterologia, Universita` degli Studi di Bologna, Bologna 40138, Italy. (literal)
Titolo
  • Mineralization behaviour with mesenchymal stromal cells in a biomimetic hyaluronic acid-based scaffold (literal)
Abstract
  • A biomimetic hyaluronic acid (HA)-based polymer scaffold was analysed in vitro for its characteristics and potential to support mineralization as carrier-vehicle. Biomimetic apatite crystal nucleation on the scaffold surface was obtained by a fine control of the pH level that increased ionic solubility thus controlling apatite formation kinetic. Different concentrations of human mesenchymal stromal cells (h-MSCs) were seeded on the scaffold, osteogenesis was induced in the presence or absence of fibroblast growth factor -2 and mineralization was analysed at different time points. We found that only at the highest h-MSCs concentration tested, the cells were uniformly distributed inside and outside the scaffold and proliferation started to decrease from day 7. Electron microscopy analysis evidenced that h-MSCs produced extracellular matrix but did not establish a direct contact with the scaffold. We found mineralized calcium-positive areas mainly present along the backbone of the scaffold starting from day 21 and increasing at day 35. FGF-2 treatment did not accelerate or increase mineralization. Non-biomimetic HA-based control scaffold showed immature mineralized areas only at day 35. Our data demonstrate that the biomimetic treatment of an HA-based scaffold promotes a faster mineralization process suggesting its possible use in clinics as a support for improving bone repair. (literal)
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