http://www.cnr.it/ontology/cnr/individuo/prodotto/ID27699
Mineralization behaviour with mesenchymal stromal cells in a biomimetic hyaluronic acid-based scaffold (Articolo in rivista)
- Type
- Label
- Mineralization behaviour with mesenchymal stromal cells in a biomimetic hyaluronic acid-based scaffold (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.biomaterials.2010.01.148 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Cristina Manferdini; Vincenzo Guarino; Nicoletta Zini; Maria Grazia Raucci; Andrea Ferrari; Francesco Grassi; Elena Gabusi; Stefano Squarzoni; Andrea Facchini; Luigi Ambrosio (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Istituto Ortopedico Rizzoli, Via di Barbiano 1/10, Bologna 40136, Italy;
Institute of Composite and Biomedical Materials, National Research Council, Naples, Italy;
IGM-CNR, Sezione di Bologna c/o Istituto Ortopedico Rizzoli, Bologna 40136, Italy;
SC Laboratorio Biologia Cellulare Muscoloscheletrica, Istituto Ortopedico Rizzoli, Bologna 40136, Italy;
Dipartimento di Medicina Interna e Gastroenterologia, Universita` degli Studi di Bologna, Bologna 40138, Italy. (literal)
- Titolo
- Mineralization behaviour with mesenchymal stromal cells in a biomimetic hyaluronic acid-based scaffold (literal)
- Abstract
- A biomimetic hyaluronic acid (HA)-based polymer scaffold was analysed in vitro for its characteristics and potential to support mineralization as carrier-vehicle. Biomimetic apatite crystal nucleation on the scaffold surface was obtained by a fine control of the pH level that increased ionic solubility thus controlling apatite formation kinetic. Different concentrations of human mesenchymal stromal cells (h-MSCs) were seeded on the scaffold, osteogenesis was induced in the presence or absence of fibroblast growth factor -2 and mineralization was analysed at different time points. We found that only at the highest h-MSCs concentration tested, the cells were uniformly distributed inside and outside the scaffold and proliferation started to decrease from day 7. Electron microscopy analysis evidenced that h-MSCs produced extracellular matrix but did not establish a direct contact with the scaffold. We found mineralized calcium-positive areas mainly present along the backbone of the scaffold starting from day 21 and increasing at day 35. FGF-2 treatment did not accelerate or increase mineralization. Non-biomimetic HA-based control scaffold showed immature mineralized areas only at day 35. Our data demonstrate that the biomimetic treatment of an HA-based scaffold promotes a faster mineralization process suggesting its possible use in clinics as a support for improving bone repair. (literal)
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