Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. (Articolo in rivista)

Type
Label
  • Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. (Articolo in rivista) (literal)
Anno
  • 2011-01-01T00:00:00+01:00 (literal)
Alternative label
  • Gemma S, Butini S, Campiani G, Brindisi M, Zanoli S, Romano MP, Tripaldi P, Savini L, Fiorini I, Borrelli G, Novellino E, Maga G. (2011)
    Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase.
    in Bioorganic & medicinal chemistry letters (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Gemma S, Butini S, Campiani G, Brindisi M, Zanoli S, Romano MP, Tripaldi P, Savini L, Fiorini I, Borrelli G, Novellino E, Maga G. (literal)
Pagina inizio
  • 2766 (literal)
Pagina fine
  • 2779 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 21(9) (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • University of Siena, Italy IGM-CNR, Pavia, Italy (literal)
Titolo
  • Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. (literal)
Abstract
  • Among the enzymes involved in the life cycle of HCV, the non-structural protein NS3, with its double function of protease and NTPase/helicase, is essential for the virus replication. Exploiting our previous knowledge in the development of nucleotide-mimicking NS3 helicase (NS3h) inhibitors endowed with key structural and electronic features necessary for an optimal ligand-enzyme interaction, we developed the tetrahydroacridinyl derivative 3a as the most potent NS3h competitive inhibitor reported to date (HCV NS3h K(i)=20nM). (literal)
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