http://www.cnr.it/ontology/cnr/individuo/prodotto/ID27688
Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. (Articolo in rivista)
- Type
- Label
- Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. (Articolo in rivista) (literal)
- Anno
- 2011-01-01T00:00:00+01:00 (literal)
- Alternative label
Gemma S, Butini S, Campiani G, Brindisi M, Zanoli S, Romano MP, Tripaldi P, Savini L, Fiorini I, Borrelli G, Novellino E, Maga G. (2011)
Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase.
in Bioorganic & medicinal chemistry letters (Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Gemma S, Butini S, Campiani G, Brindisi M, Zanoli S, Romano MP, Tripaldi P, Savini L, Fiorini I, Borrelli G, Novellino E, Maga G. (literal)
- Pagina inizio
- Pagina fine
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- University of Siena, Italy
IGM-CNR, Pavia, Italy (literal)
- Titolo
- Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase. (literal)
- Abstract
- Among the enzymes involved in the life cycle of HCV, the non-structural protein NS3, with its double function of protease and NTPase/helicase, is essential for the virus replication. Exploiting our previous knowledge in the development of nucleotide-mimicking NS3 helicase (NS3h) inhibitors endowed with key structural and electronic features necessary for an optimal ligand-enzyme interaction, we developed the tetrahydroacridinyl derivative 3a as the most potent NS3h competitive inhibitor reported to date (HCV NS3h K(i)=20nM). (literal)
- Prodotto di
- Autore CNR
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