G93A SOD1 alters cell cycle in a cellular model of Amyotrophic Lateral Sclerosis (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• G93A SOD1 alters cell cycle in a cellular model of Amyotrophic Lateral Sclerosis (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.cellsig.2010.05.016 (literal)

Alternative label

• Cova E;1 Ghiroldi A;1 Guareschi S;1 Mazzini G;3 Gagliardi S;1 Davin A;4 Bianchi M;4 Ceroni M;1,4 Cereda C.1 (2010)
  G93A SOD1 alters cell cycle in a cellular model of Amyotrophic Lateral Sclerosis
  in Cellular signalling
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Cova E;1 Ghiroldi A;1 Guareschi S;1 Mazzini G;3 Gagliardi S;1 Davin A;4 Bianchi M;4 Ceroni M;1,4 Cereda C.1 (literal)

Pagina inizio

• 1477 (literal)

Pagina fine

• 1484 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 22 (literal)

Rivista

• Cellular signalling (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 10 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• 1. Natl Neurol Inst C Mondino, Lab Expt Neurobiol, IRCCS, I-27100 Pavia, Italy 2. Univ Pavia, Dept Neurosci, I-27100 Pavia, Italy 3. Univ Pavia, IGM, CNR, Dept Anim Biol, I-27100 Pavia, Italy 4. Natl Neurol Inst C Mondino, Div Gen Neurol IRCCS, I-27100 Pavia, Italy (literal)

Titolo

• G93A SOD1 alters cell cycle in a cellular model of Amyotrophic Lateral Sclerosis (literal)

Abstract

• Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative multifactorial disease characterized, like other diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) or frontotemporal dementia (FTD), by the degeneration of specific neuronal cell populations. Motor neuron loss is distinctive of ALS. However, the causes of onset and progression of motor neuron death are still largely unknown. In about 2% of all cases, mutations in the gene encoding for the Cu/Zn superoxide dismutase (SOD1) are implicated in the disease. Several alterations in the expression or activation of cell cycle proteins have been described in the neurodegenerative diseases and related to cell death. In this work we show that mutant SOD1 can alter cell cycle in a cellular model of ALS. Our findings suggest that modifications in the cell cycle progression could be due to an increased interaction between mutant G93A SOD1 and Bcl-2 through the cyclins regulator p27. As previously described in post mitotic neurons, cell cycle alterations could fatally lead to cell death. Copyright © 2010. Published by Elsevier Inc. (literal)

Prodotto di

• Institute of molecular genetics (IGM) (Istituto)
• Sviluppi metodologici in citometria e applicazioni alla sperimentazione biomedica; in vitro imaging (ME.P06.010.001) (Modulo)

Autore CNR

• GIULIANO MAZZINI (Persona)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Sviluppi metodologici in citometria e applicazioni alla sperimentazione biomedica; in vitro imaging (ME.P06.010.001) (Modulo)

Autore CNR di

• GIULIANO MAZZINI (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Cellular signalling (Rivista)