Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: Therapeutic potential of bifunctional oligonucleotides and indole derivatives (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: Therapeutic potential of bifunctional oligonucleotides and indole derivatives (Articolo in rivista) (literal)

Anno

• 2010-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.4161/rna.7.4.12744 (literal)

Alternative label

• Ghigna C; De Toledo M; Bonomi S; Valacca C; Gallo S; Apicella M: Eperon I; Taz Ji; Biamonti G (2010)
  Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: Therapeutic potential of bifunctional oligonucleotides and indole derivatives
  in RNA (Camb., Print); Cambridge University Press, Cambridge (Regno Unito)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ghigna C; De Toledo M; Bonomi S; Valacca C; Gallo S; Apicella M: Eperon I; Taz Ji; Biamonti G (literal)

Pagina inizio

• 495 (literal)

Pagina fine

• 503 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.landesbioscience.com/journals/rnabiology/article/12744/?nocache=672052345 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 7 (literal)

Rivista

• RNA (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• ISI Web of Science (WOS) (literal)
• PubMe (literal)
• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Genetica Molecolare - Consiglio Nazionale delle Ricerche (IGM-cNR), pavia, italy; University of Montpellier II, Institute of Molecular Genetics, Centre Nationale de Recherche Scientifique, Montpellier, France; Department of Biochemistry, University of Leicester, Leicester, UK; (literal)

Titolo

• Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: Therapeutic potential of bifunctional oligonucleotides and indole derivatives (literal)

Abstract

• Alternative splicing is a key molecular mechanism for increasing the complexity of the human transcriptome. Nearly all human genes are regulated by alternative splicing and the deregulation of this process has a causative role in various human diseases, including cancer. The discovery that alternatively spliced isoforms of several genes are expressed selectively in tumour cells opened the exciting possibility that pharmacological treatment of aberrant splicing could lead to new anti-cancer therapeutic approaches. An alternatively spliced isoform of a scatter factor receptor and proto-oncogene, Ron, accumulates during tumour progression of epithelial tissues and is able to confer an invasive phenotype to the expressing cells. This isoform, called ”Ron, originates from skipping of exon 11, and this specific splicing event is controlled by the expression level of the splicing factor and proto-oncogene SF2/ASF. Over-expression of SF2/ASF, which occurs frequently in various human tumors, induces the production of ”Ron and activates the epithelial to mesenchymal transition (EMT), leading to increased cell motility. In this paper, we have used targeted oligonucleotide enhancers of splicing (TOES) to recruit positive splicing factors to Ron exon 11 and thereby stimulate its inclusion. As an alternative approach, we have used selected indole derivatives that target ASF/SF2 splicing activity. Both treatments correct aberrant ”Ron splicing, restoring the incorporation of Ron exon 11. Notably, indole derivatives are also able to affect the invasive phenotype of the cells. Thus, these treatments may have therapeutic applications for anti-cancer purposes. (literal)

Editore

• Cambridge University Press (Editore)

Prodotto di

• Lo splicing alternativo come strumento per sviluppare nuovi approcci anti-angiogenici per controllare la crescita del cancro (SV.P13.001.003) (Modulo)
• Studio della regolazione post-trascrizionale dell'espressione genica in risposta a stress. Fattori che controllano lo splicing dei mRNA in cellule normali e nei tumori. (SV.P13.001.001) (Modulo)
• Institute of molecular genetics (IGM) (Istituto)

Autore CNR

• GIUSEPPE BIAMONTI (Unità di personale interno)
• Cristina Valacca (Unità di personale esterno)
• SERENA BONOMI (Persona)
• CLAUDIA GHIGNA (Unità di personale interno)

Insieme di parole chiave

• Parole chiave di "Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: Therapeutic potential of bifunctional oligonucleotides and indole derivatives" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Lo splicing alternativo come strumento per sviluppare nuovi approcci anti-angiogenici per controllare la crescita del cancro (SV.P13.001.003) (Modulo)
• Studio della regolazione post-trascrizionale dell'espressione genica in risposta a stress. Fattori che controllano lo splicing dei mRNA in cellule normali e nei tumori. (SV.P13.001.001) (Modulo)

Autore CNR di

• GIUSEPPE BIAMONTI (Unità di personale interno)
• CLAUDIA GHIGNA (Unità di personale interno)
• SERENA BONOMI (Persona)
• Cristina Valacca (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• RNA (Rivista)

Editore di

• Cambridge University Press (Editore)

Insieme di parole chiave di

• Parole chiave di "Pro-metastatic splicing of Ron proto-oncogene mRNA can be reversed: Therapeutic potential of bifunctional oligonucleotides and indole derivatives" (Insieme di parole chiave)