Autoantibodies to poly(ADP-ribose) polymerase in centenarians: a reappraisal of Grabar's hypothesis. (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Autoantibodies to poly(ADP-ribose) polymerase in centenarians: a reappraisal of Grabar's hypothesis. (Articolo in rivista) (literal)

Anno

• 2009-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1159/000213652 (literal)

Alternative label

• Lisa A, Monti D, Franceschi C, Scovassi AI (2009)
  Autoantibodies to poly(ADP-ribose) polymerase in centenarians: a reappraisal of Grabar's hypothesis.
  in Gerontology (Basel)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Lisa A, Monti D, Franceschi C, Scovassi AI (literal)

Pagina inizio

• 427 (literal)

Pagina fine

• 429 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://content.karger.com/produktedb/produkte.asp?DOI=10.1159/000213652 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 55 (literal)

Rivista

• Gerontology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 4 (literal)

Note

• Scopus (literal)
• PubMe (literal)
• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Genetica Molecolare CNR, Pavia, dipartimento di Oncologia e Patologia Sperimentale, Universita di Firenze, Firenze, e Dipartimento di Patologia Sperimentale, Universita di Bologna, Bologna, Italia (literal)

Titolo

• Autoantibodies to poly(ADP-ribose) polymerase in centenarians: a reappraisal of Grabar's hypothesis. (literal)

Abstract

• Background: Centenarians display a characteristic auto- antibody profile, this being the absence of organ-specific autoantibodies and an increase in non-organ-specific auto- antibodies without any full-blown autoimmune disease. Objective: Antibodies directed to the nuclear protein poly(ADP-ribose) polymerase (PARP) were frequently found in the sera of patients affected by autoimmune diseases. This study aims at investigating the presence of circulating auto- antibodies directed against PARP-1 in normal subjects, and searching for a possible correlation between level of circulat- ing autoantibodies and age. Methods: The presence of anti- bodies to PARP was monitored by ELISA according to a previ- ously developed protocol. Data were analysed by parametric statistics (unpaired t test, :2 test). Results: Our study per- formed on 33 centenarians and 66 subjects of age ranging from 12 to 80 years shows that circulating autoantibodies to the nuclear enzyme PARP, previously described in autoim- mune diseases, are present in the sera of normal healthy people and increase with age. Conclusions: Taking into ac- count the role of PARP-1 in DNA damage and apoptosis, the data are compatible with Grabar’s hypothesis, which pro- posed several decades ago that ‘autoreactive antibodies represent a physiological system for disposing the products of metabolism and catabolism’, thereby helping to attain longevity. (literal)

Prodotto di

• Cromosomi artificiali per terapia genica. Studi sulla replicazione del DNA in cellule umane ; controllo del ciclo cellulare e della proliferazione. (ME.P05.006.001) (Modulo)
• Institute of molecular genetics (IGM) (Istituto)
• Biologia Computazionale (ME.P07.005.001) (Modulo)

Autore CNR

• ANTONELLA LISA (Persona)
• ANNA SCOVASSI (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Autoantibodies to poly(ADP-ribose) polymerase in centenarians: a reappraisal of Grabar's hypothesis." (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Biologia Computazionale (ME.P07.005.001) (Modulo)
• Cromosomi artificiali per terapia genica. Studi sulla replicazione del DNA in cellule umane ; controllo del ciclo cellulare e della proliferazione. (ME.P05.006.001) (Modulo)

Autore CNR di

• ANNA SCOVASSI (Unità di personale interno)
• ANTONELLA LISA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Gerontology (Rivista)

Insieme di parole chiave di

• Keywords of "Autoantibodies to poly(ADP-ribose) polymerase in centenarians: a reappraisal of Grabar's hypothesis." (Insieme di parole chiave)