Biological effects of a new v-H-ATPase inhibitor in colon carcinoma cell lines. (Articolo in rivista)

Type
Label
  • Biological effects of a new v-H-ATPase inhibitor in colon carcinoma cell lines. (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1196/annals.1397.021 (literal)
Alternative label
  • Supino R; Scovassi AI; Croce AC; Dal Bo L; Favini E; Corbelli A; Farina C; Misiano P; Zunino F (2009)
    Biological effects of a new v-H-ATPase inhibitor in colon carcinoma cell lines.
    in Annals of the New York Academy of Sciences
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Supino R; Scovassi AI; Croce AC; Dal Bo L; Favini E; Corbelli A; Farina C; Misiano P; Zunino F (literal)
Pagina inizio
  • 606 (literal)
Pagina fine
  • 616 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 1171 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#descrizioneSinteticaDelProdotto
  • Pubblicazione scientifica (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • Scopus (literal)
  • PubMe (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • IGM-CNR; Istituto Nazionale Tumori, Milano; Consorzio (Microscopy and Image Analysis), Universita' degli Studi di Milano - Bicocca,Milano; Brane Discovery S.r.l., Gerenzano (literal)
Titolo
  • Biological effects of a new v-H-ATPase inhibitor in colon carcinoma cell lines. (literal)
Abstract
  • Vacuolar-H+-ATPase plays a critical role in the cellular balance of protons thus regulating intracellular pH and contributing to apoptosis resistance, drug resistance and invasive and metastatic behaviour of cells NiK-12192, a Vacuolar-H+-ATPase inhibitor, caused a reduction in the volume and/or acidity of lysosomes, a polarization of ±v²5 integrin distribution, and a number of floating alive cells whereas signs of apoptosis appeared only after 72 h of treatment In conclusion, NiK-12192, by affecting Vacuolar- H+-ATPase activity (and intracellular pH) causes a modification of structures crucial for the cell adhesion and induces cell death likely by a modality involving an anoikis-mediated apoptosis (literal)
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