Proteomics-based investigation in C2C12 myoblast differentiation (Articolo in rivista)

Type
Label
  • Proteomics-based investigation in C2C12 myoblast differentiation (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Alternative label
  • Casadei L, Vallorani L, Gioacchini AM, Guescini M, Burattini S, D'Emilio A, Biagiotti L, Falcieri E, Stocchi V. (2009)
    Proteomics-based investigation in C2C12 myoblast differentiation
    in European journal of histochemistry (Testo stamp.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Casadei L, Vallorani L, Gioacchini AM, Guescini M, Burattini S, D'Emilio A, Biagiotti L, Falcieri E, Stocchi V. (literal)
Pagina inizio
  • 261 (literal)
Pagina fine
  • 268 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 53 (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Dipartimento di Scienze Biomolecolari, Università degli Studi di Urbino \"Carlo Bo\", Urbino; DISUAN, Università degli Studi di Urbino “Carlo Bo”, Urbino; IGM, CNR, Istituti Ortopedici Rizzoli, Bologna, Italy (literal)
Titolo
  • Proteomics-based investigation in C2C12 myoblast differentiation (literal)
Abstract
  • Skeletal muscle cell differentiation is a multistage process extensively studied over the years. Even if great improvements have been achieved in defining biological process underlying myogenesis, many molecular mechanisms need still to be clarified. To further highlight this process, we studied cells at undifferentiated, intermediate and highly differentiated stages, and we analyzed, for each condition, morphological and proteomic changes. We also identified the proteins that showed statistical significant changes by a ESI-Q-TOF mass spectrometer. This work provides further evidence of the involvement of particular proteins in skeletal muscle development. Furthermore, the high level of expression of many heat shock proteins, suggests a relationship between differentiation and cellular stress. Intriguingly, the discovery of myogenesis-correlated proteins, known to play a role in apoptosis, suggests a link between differentiation and this type of cell death. (literal)
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