GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation (Articolo in rivista)

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Label
  • GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.4161/cc.26771 (literal)
Alternative label
  • Velletri Tania; Romeo Francesco; Tucci Paola; Peschiaroli Angelo; Annicchiarico-Petruzzelli Margherita; Niklison-Chirou Maria Victoria; Amelio Ivano; Knight Richard A.; Mak Tak W.; Melino Gerry; Agostini Massimiliano (2013)
    GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation
    in Cell cycle (Georget. Tex.)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Velletri Tania; Romeo Francesco; Tucci Paola; Peschiaroli Angelo; Annicchiarico-Petruzzelli Margherita; Niklison-Chirou Maria Victoria; Amelio Ivano; Knight Richard A.; Mak Tak W.; Melino Gerry; Agostini Massimiliano (literal)
Pagina inizio
  • 3564 (literal)
Pagina fine
  • 3573 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#altreInformazioni
  • Epub 2013 Oct 10 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 12 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 22 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • - Tania Velletri: Medical Research Council; Toxicology Unit; Leicester University; Leicester, UK; Institute of Health Sciences; Shanghai Institutes for Biological Sciences; Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine; Shanghai, China. - Francesco Romeo: Department of Experimental and Clinical Medicine; Magna Græcia University of Catanzaro; Catanzaro, Italy. - Paola Tucci: Medical Research Council; Toxicology Unit; Leicester University; Leicester, UK; Department of Pharmaco-Biology; University of Calabria; Rende, Cosenza, Italy. - Angelo Peschiaroli: Institute of Cellular Biology and Neurobiology; CNR; Rome, Italy. - Margherita Annicchiarico-Petruzzelli: Biochemistry Laboratory IDI-IRCC; Department of Experimental Medicine and Surgery; University of Rome \"Tor Vergata\"; Rome, Italy. - Maria Victoria Niklison-Chirou: Medical Research Council; Toxicology Unit; Leicester University; Leicester, UK. - Ivano Amelio: Medical Research Council; Toxicology Unit; Leicester University; Leicester, UK. - Richard A Knight: Medical Research Council; Toxicology Unit; Leicester University; Leicester, UK. - Tak W Mak: The Campbell Family Institute for Breast Cancer Research; Princess Margaret Hospital; Toronto, Ontario, Canada. - Gerry Melino: Medical Research Council; Toxicology Unit; Leicester University; Leicester, UK; Biochemistry Laboratory IDI-IRCC; Department of Experimental Medicine and Surgery; University of Rome \"Tor Vergata\"; Rome, Italy. - Massimiliano Agostini: Medical Research Council; Toxicology Unit; Leicester University; Leicester, UK. (literal)
Titolo
  • GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation (literal)
Abstract
  • The amino acid Glutamine is converted into Glutamate by a deamidation reaction catalyzed by the enzyme Glutaminase (GLS). Two isoforms of this enzyme have been described, and the GLS2 isoform is regulated by the tumor suppressor gene p53. Here, we show that the p53 family member TAp73 also drives the expression of GLS2. Specifically, we demonstrate that TAp73 regulates GLS2 during retinoic acid-induced terminal neuronal differentiation of neuroblastoma cells, and overexpression or inhibition of GLS2 modulates neuronal differentiation and intracellular levels of ATP. Moreover, inhibition of GLS activity, by removing Glutamine from the growth medium, impairs in vitro differentiation of cortical neurons. Finally, expression of GLS2 increases during mouse cerebellar development. Although, p73 is dispensable for the in vivo expression of GLS2, TAp73 loss affects GABA and Glutamate levels in cortical neurons. Together, these findings suggest a role for GLS2 acting, at least in part, downstream of p73 in neuronal differentiation and highlight a possible role of p73 in regulating neurotransmitter synthesis. (literal)
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