http://www.cnr.it/ontology/cnr/individuo/prodotto/ID27615
Gene array profile identifies collagen type XV as a novel human osteoblast-secreted matrix protein (Articolo in rivista)
- Type
- Label
- Gene array profile identifies collagen type XV as a novel human osteoblast-secreted matrix protein (Articolo in rivista) (literal)
- Anno
- 2009-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1002/jcp.21779 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Gina Lisignoli; Katia Codeluppi; Katia Todoerti; Cristina Manferdini; Anna Piacentini; Nicoletta Zini; Francesco Grassi; Luca Cattini; Roberta Piva; Vittorio Rizzoli; Andrea Facchini; Nicola Giuliani; Antonino Neri (literal)
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- Rivista
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Laboratorio di Immunologia e Genetica, Istituto Ortopedico Rizzoli, Bologna, Italy;
Ematologia I, Fondazione IRCCS Policlinico, Milan, Italy;
IGM-CNR, Sezione di Bologna c/o IOR, Bologna, Italy;
Dipartimento di Biochimica e Biologia Molecolare, Sezione di Biologia Molecolare, Universita' degli Studi di Ferrara, Ferrara, Italy;
Ematologia e Centro trapianti midollo osseo, Dipartimento di Medicina Interna e Scienze Biomediche, Universita' di Parma, Parma, Italy;
Dipartimento di Medicina Interna e Gastroenterologia, Universita' degli Studi di Bologna, Bologna, Italy;
Dipartimento di Scienze Mediche, Università degli Studi di Milano, Milan, Italy
Dipartimento di Scienze Mediche, Universita` degli Studi di Milano, Milan, Italy (literal)
- Titolo
- Gene array profile identifies collagen type XV as a novel human osteoblast-secreted matrix protein (literal)
- Abstract
- Bone marrow stromal cells (MSCs) and osteoblasts are the two main non-haematopoietic cellular components of human bone tissue. To identify novel osteoblast-related molecules, we performed a gene expression profiling analysis comparing MSCs and osteoblasts isolated from the same donors. Genes differentially overexpressed in osteoblasts were mainly related to the negative control of cell proliferation, pro-apoptotic processes, protein metabolism and bone remodelling. Notably, we also identified the collagen XV (COL15A1) gene as the most up-regulated gene in osteoblasts compared with MSCs, previously described as being expressed in the basement membrane in other cell types. The expression of collagen type XV was confirmed at the protein level on isolated osteoblasts and we demonstrated that it significantly increases during the osteogenic differentiation of MSCs in vitro and that free ionised extracellular calcium significantly down-modulates its expression. Moreover, light and electron microscopy showed that collagen type XV is expressed in bone tissue biopsies mainly by working osteoblasts forming new bone tissue or lining bone trabeculae. To our knowledge, these data represent the first evidence of the expression of collagen type XV in human osteoblasts, a calcium-regulated protein which correlates to a specific functional state of these cells. (literal)
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