Surface-dependent modulation of proliferation, bone matrix molecules, and inflammatory factors in human osteoblasts (Articolo in rivista)

Type
Label
  • Surface-dependent modulation of proliferation, bone matrix molecules, and inflammatory factors in human osteoblasts (Articolo in rivista) (literal)
Anno
  • 2009-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/jbm.a.32019 (literal)
Alternative label
  • Beatrice Tonnarelli; Cristina Manferdini; Anna Piacentini; Katia Codeluppi; Nicoletta Zini; Sonia Ghisu; Andrea Facchini; Gina Lisignoli (2009)
    Surface-dependent modulation of proliferation, bone matrix molecules, and inflammatory factors in human osteoblasts
    in Journal of biomedical materials research. Part A
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Beatrice Tonnarelli; Cristina Manferdini; Anna Piacentini; Katia Codeluppi; Nicoletta Zini; Sonia Ghisu; Andrea Facchini; Gina Lisignoli (literal)
Pagina inizio
  • 687 (literal)
Pagina fine
  • 696 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 89A (literal)
Rivista
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Laboratorio di Immunologia e Genetica, Istituti Ortopedici Rizzoli, Bologna, Italy; IGM - CNR, Sezione di Bologna c/o Istituti Ortopedici Rizzoli, 40136 Bologna, Italy; Laboratorio di Biologia Cellulare e Microscopia Elettronica, Istituti Ortopedici Rizzoli, 40136 Bologna, Italy; Dipartimento di Medicina Interna e Gastroenterologia, Università degli Studi di Bologna, Italy (literal)
Titolo
  • Surface-dependent modulation of proliferation, bone matrix molecules, and inflammatory factors in human osteoblasts (literal)
Abstract
  • Surface properties affect the biological properties of cells modulating the expression of different factors. Osteoblasts contribute both to new bone formation and controlling haematopoiesis through cytokines and growth factors. We analyzed the effect of bone (calcium-phosphate bone slides), cartilaginous (hyaluronan-based scaffold), and plastic substrate culture on human osteoblast proliferation, bone matrix molecule, and inflammatory factor expression. Osteoblast proliferation increased to a greater extent when the cells were grown for 14 days on plastic and bone slides, whereas hyaluronan-based scaffold (HA-scaffold) induced only a minimal increase. Collagen type I, osteonectin, alkaline phosphatase and osteocalcin were expressed on osteoblasts grown on plastic and bone slides and down-modulated at mRNA and protein level by HA-scaffold. Bone slides showed the ability to increase osteopontin mRNA expression. The expression of CXCR4 and CXCL13 was upregulated by bone slides and HA-scaffold, while CXCL12 and CXCR5 expression was down-modulated. These data suggest a substrate-dependent modulation of human osteoblast proliferation, bone matrix and inflammatory factor expression, which might help to understand the active role played by osteoblasts in bone microenvironment by coupling bone extracellular matrix, chemokines and the haematopoietic system. (literal)
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