http://www.cnr.it/ontology/cnr/individuo/prodotto/ID275827
Greening the Valsartan Synthesis: Scale-up of Key Suzuki-Miyaura Coupling over Silia Cat DPP-Pd (Articolo in rivista)
- Type
- Label
- Greening the Valsartan Synthesis: Scale-up of Key Suzuki-Miyaura Coupling over Silia Cat DPP-Pd (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1021/op400118f (literal)
- Alternative label
Pandarus, V., Desplantier-Giscard, D., Gingras, G., Béland, F., Ciriminna, R., Pagliaro, M. (2013)
Greening the Valsartan Synthesis: Scale-up of Key Suzuki-Miyaura Coupling over Silia Cat DPP-Pd
in Organic process research & development; Royal Society of Chemistry, Cambridge (Regno Unito)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Pandarus, V., Desplantier-Giscard, D., Gingras, G., Béland, F., Ciriminna, R., Pagliaro, M. (literal)
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- SiliCycle Inc., Quebec City, QC G1P 4S6, Canada;
Istituto per Lo Studio Dei Materiali Nanostrutturati, CNR, Palermo, Italy. (literal)
- Titolo
- Greening the Valsartan Synthesis: Scale-up of Key Suzuki-Miyaura Coupling over Silia Cat DPP-Pd (literal)
- Abstract
- The study of the scale-up of the heterogeneous Suzuki-Miyaura coupling reaction in batch conditions between 2-chlorobenzonitrile and 4-tolylboronic acid, a key step in valsartan synthesis, to produce 4?-methyl-2- biphenylcarbonitrile over the SiliaCat DPP-Pd catalyst in ethanol under reflux allows to identify the optimal reaction conditions. The catalyst, regardless of limited Pd leaching, is not reusable, and the method can be effectively applied to the high yield synthesis of several coupling products, opening the route to efficient continuous coupling syntheses. (literal)
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