PARP inhibitors: new tools to protect from inflammation. (Articolo in rivista)

Type
Label
  • PARP inhibitors: new tools to protect from inflammation. (Articolo in rivista) (literal)
Anno
  • 2010-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1016/j.bcp.2010.04.022 (literal)
Alternative label
  • Giansanti V, Donà F, Tillhon M, Scovassi AI. (2010)
    PARP inhibitors: new tools to protect from inflammation.
    in Biochemical pharmacology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Giansanti V, Donà F, Tillhon M, Scovassi AI. (literal)
Pagina inizio
  • 1869 (literal)
Pagina fine
  • 1877 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.ncbi.nlm.nih.gov/pubmed/20417190 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 80 (literal)
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  • Review (literal)
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  • Pubblicazione scientifica (literal)
Note
  • ISI Web of Science (WOS) (literal)
  • PubMe (literal)
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • IGM-CNR (literal)
Titolo
  • PARP inhibitors: new tools to protect from inflammation. (literal)
Abstract
  • Poly(ADP-ribosylation) consists in the conversion of ss-NAD(+) into ADP-ribose, which is then bound to acceptor proteins and further used to form polymers of variable length and structure. The correct turnover of poly(ADP-ribose) is ensured by the concerted action of poly(ADP-ribose) polymerase (PARP) and poly(ADP-ribose) glycohydrolase (PARG) enzymes, which are responsible for polymer synthesis and degradation, respectively. Despite the positive role of poly(ADP-ribosylation) in sensing and repairing DNA damage, generated also by ROS, PARP over-activation could allow NAD depletion and consequent necrosis, thus leading to an inflammatory condition in many diseases. In this respect, inhibition of PARP enzymes could exert a protective role towards a number of pathological conditions; i.e. the combined treatment of tumors with PARP inhibitors/anticancer agents proved to have a beneficial effect in cancer therapy. Thus, pharmacological inactivation of poly(ADP-ribosylation) could represent a novel therapeutic strategy to limit cellular injury and to attenuate the inflammatory processes that characterize many disorders. Copyright © 2010. Published by Elsevier Inc. (literal)
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