http://www.cnr.it/ontology/cnr/individuo/prodotto/ID27556
PARP inhibitors: new tools to protect from inflammation. (Articolo in rivista)
- Type
- Label
- PARP inhibitors: new tools to protect from inflammation. (Articolo in rivista) (literal)
- Anno
- 2010-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.bcp.2010.04.022 (literal)
- Alternative label
Giansanti V, Donà F, Tillhon M, Scovassi AI. (2010)
PARP inhibitors: new tools to protect from inflammation.
in Biochemical pharmacology
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Giansanti V, Donà F, Tillhon M, Scovassi AI. (literal)
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- http://www.ncbi.nlm.nih.gov/pubmed/20417190 (literal)
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- Titolo
- PARP inhibitors: new tools to protect from inflammation. (literal)
- Abstract
- Poly(ADP-ribosylation) consists in the conversion of ss-NAD(+) into ADP-ribose, which is then bound to acceptor proteins and further used to form polymers of variable length and structure. The correct turnover of poly(ADP-ribose) is ensured by the concerted action of poly(ADP-ribose) polymerase (PARP) and poly(ADP-ribose) glycohydrolase (PARG) enzymes, which are responsible for polymer synthesis and degradation, respectively. Despite the positive role of poly(ADP-ribosylation) in sensing and repairing DNA damage, generated also by ROS, PARP over-activation could allow NAD depletion and consequent necrosis, thus leading to an inflammatory condition in many diseases. In this respect, inhibition of PARP enzymes could exert a protective role towards a number of pathological conditions; i.e. the combined treatment of tumors with PARP inhibitors/anticancer agents proved to have a beneficial effect in cancer therapy. Thus, pharmacological inactivation of poly(ADP-ribosylation) could represent a novel therapeutic strategy to limit cellular injury and to attenuate the inflammatory processes that characterize many disorders. Copyright © 2010. Published by Elsevier Inc. (literal)
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