Growth-promoting action and growth factor release by different platelet derivatives. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Growth-promoting action and growth factor release by different platelet derivatives. (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Alternative label

• Passaretti F, Tia M, D'Esposito V, Pascale MD, Corso MD, Sepulveres R, Liguoro D, Valentino R, Beguinot F, Formisano P, Sammartino G. (2014)
  Growth-promoting action and growth factor release by different platelet derivatives.
  in Platelets (Sheff.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Passaretti F, Tia M, D'Esposito V, Pascale MD, Corso MD, Sepulveres R, Liguoro D, Valentino R, Beguinot F, Formisano P, Sammartino G. (literal)

Rivista

• Platelets (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Translational Medical Sciences, Federico II University of Naples , Naples , Italy . (literal)

Titolo

• Growth-promoting action and growth factor release by different platelet derivatives. (literal)

Abstract

• Abstract Platelet derivatives are commonly used in wound healing and tissue regeneration. Different procedures of platelet preparation may differentially affect growth factor release and cell growth. Preparation of platelet-rich fibrin (PRF) is accompanied by release of growth factors, including platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and transforming growth factor ?1 (TGF?1), and several cytokines. When compared with the standard procedure for platelet-rich plasma (PRP), PRF released 2-fold less PDGF, but >15-fold and >2-fold VEGF and TGF?1, respectively. Also, the release of several cytokines (IL-4, IL-6, IL-8, IL-10, IFN?, MIP-1?, MIP-1? and TNF?) was significantly increased in PRF-conditioned medium (CM), compared to PRP-CM. Incubation of both human skin fibroblasts and human umbilical vein endothelial cells (HUVECs) with PRF-derived membrane (mPRF) or with PRF-CM enhanced cell proliferation by >2-fold (p < 0.05). Interestingly, PRP elicited fibroblast growth at a higher extent compared to PRF. At variance, PRF effect on HUVEC growth was significantly greater than that of PRP, consistent with a higher concentration of VEGF in the PRF-CM. Thus, the procedure of PRP preparation leads to a larger release of PDGF, as a possible result of platelet degranulation, while PRF enhances the release of proangiogenic factors. (literal)

Prodotto di

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Strategie innovative per la terapia e la diagnosi dei tumori (SV.P15.001.005) (Modulo)

Autore CNR

• PIETRO FORMISANO (Persona)
• FRANCESCO BEGUINOT (Unità di personale esterno)
• ROSSELLA VALENTINO (Persona)
• DOMENICO LIGUORO (Persona)

Incoming links:

Autore CNR di

• ROSSELLA VALENTINO (Persona)
• FRANCESCO BEGUINOT (Unità di personale esterno)
• DOMENICO LIGUORO (Persona)
• PIETRO FORMISANO (Persona)

Prodotto

• Istituto per l'endocrinologia e l'oncologia \"Gaetano Salvatore\" (IEOS) (Istituto)
• Strategie innovative per la terapia e la diagnosi dei tumori (SV.P15.001.005) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Platelets (Rivista)