http://www.cnr.it/ontology/cnr/individuo/prodotto/ID275466
Phylogenetic Study of Polyketide Synthases and Nonribosomal Peptide Synthetases Involved in the Biosynthesis of Mycotoxins (Articolo in rivista)
- Type
- Label
- Phylogenetic Study of Polyketide Synthases and Nonribosomal Peptide Synthetases Involved in the Biosynthesis of Mycotoxins (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.3390/toxins5040717 (literal)
- Alternative label
Gallo A, Ferrara M, Perrone G (2013)
Phylogenetic Study of Polyketide Synthases and Nonribosomal Peptide Synthetases Involved in the Biosynthesis of Mycotoxins
in Toxins (Basel); MDPI AG, Basel (Swaziland)
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- Gallo A, Ferrara M, Perrone G (literal)
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- Google Scholar (literal)
- PubMe (literal)
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Istituto di Scienze delle Produzioni Alimentari (ISPA)-CNR, Bari (literal)
- Titolo
- Phylogenetic Study of Polyketide Synthases and Nonribosomal Peptide Synthetases Involved in the Biosynthesis of Mycotoxins (literal)
- Abstract
- Polyketide synthase (PKSs) and nonribosomal peptide synthetase (NRPSs) are
large multimodular enzymes involved in biosynthesis of polyketide and peptide toxins
produced by fungi. Furthermore, hybrid enzymes, in which a reducing PKS region is fused
to a single NRPS module, are also responsible of the synthesis of peptide-polyketide
metabolites in fungi. The genes encoding for PKSs and NRPSs have been exposed to
complex evolutionary mechanisms, which have determined the great number and diversity
of metabolites. In this study, we considered the most important polyketide and peptide
mycotoxins and, for the first time, a phylogenetic analysis of both PKSs and NRPSs
involved in their biosynthesis was assessed using two domains for each enzyme:
?-ketosynthase (KS) and acyl-transferase (AT) for PKSs; adenylation (A) and
condensation (C) for NRPSs. The analysis of both KS and AT domains confirmed the
differentiation of the three classes of highly, partially and non-reducing PKSs. Hybrid
PKS-NRPSs involved in mycotoxins biosynthesis grouped together in the phylogenetic
trees of all the domains analyzed. For most mycotoxins, the corresponding biosynthetic
enzymes from distinct fungal species grouped together, except for PKS and NRPS
involved in ochratoxin A biosynthesis, for which an unlike process of evolution could be
hypothesized in different species. (literal)
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