http://www.cnr.it/ontology/cnr/individuo/prodotto/ID275454
Multiple mycotoxin exposure determined by urinary biomarkers in rural subsistence farmers in the former Transkei, South Africa (Articolo in rivista)
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- Label
- Multiple mycotoxin exposure determined by urinary biomarkers in rural subsistence farmers in the former Transkei, South Africa (Articolo in rivista) (literal)
- Anno
- 2013-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.fct.2013.08.040 (literal)
- Alternative label
Gordon S. Shephard a,?, Hester-Mari Burger a, Lucia Gambacorta b, Yun Yun Gong c,1, Rudolf Krska d,
John P. Rheeder a, Michele Solfrizzo b, Chou Srey c,1, Michael Sulyok d, Angelo Visconti b, Benedikt Warth d,
Liana van der Westhuizen a (2013)
Multiple mycotoxin exposure determined by urinary biomarkers in rural subsistence farmers in the former Transkei, South Africa
in Food and chemical toxicology
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Gordon S. Shephard a,?, Hester-Mari Burger a, Lucia Gambacorta b, Yun Yun Gong c,1, Rudolf Krska d,
John P. Rheeder a, Michele Solfrizzo b, Chou Srey c,1, Michael Sulyok d, Angelo Visconti b, Benedikt Warth d,
Liana van der Westhuizen a (literal)
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- a PROMEC Unit, Medical Research Council, PO Box 19070, Tygerberg 7505, South Africa
b Institute of Sciences of Food Production (ISPA), National Research Council of Italy, Bari, Italy
c Division of Epidemiology, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
d Center for Analytical Chemistry, Department for Agrobiotechnology (IFA-Tulln), University of Natural Resources and Life Sciences, Vienna (BOKU), Tulln, Austria (literal)
- Titolo
- Multiple mycotoxin exposure determined by urinary biomarkers in rural subsistence farmers in the former Transkei, South Africa (literal)
- Abstract
- Subsistence farmers are exposed to a range of mycotoxins. This study applied novel urinary multi-mycotoxin
LC-MS/MS methods to determine multiple exposure biomarkers in the high oesophageal cancer
region, Transkei, South Africa. Fifty-three female participants donated part of their maize-based evening
meal and first void morning urine, which was analysed both with sample clean-up (single and multi-biomarker)
and by a 'dilute-and-shoot' multi-biomarker method. Results were corrected for recovery with
LOD for not detected. A single biomarker method detected fumonisin B1 (FB1) (87% incidence; mean ± standard
deviation 0.342 ± 0.466 ng/mg creatinine) and deoxynivalenol (100%; mean 20.4 ± 49.4 ng/mg creatinine)
after hydrolysis with b-glucuronidase. The multi-biomarker 'dilute-and-shoot' method indicated
deoxynivalenol-15-glucuronide was predominantly present. A multi-biomarker method with b-glucuronidase
and immunoaffinity clean-up determined zearalenone (100%; 0.529 ± 1.60 ng/mg creatinine), FB1
(96%; 1.52 ± 2.17 ng/mg creatinine), a-zearalenol (92%; 0.614 ± 1.91 ng/mg creatinine), deoxynivalenol
(87%; 11.3 ± 27.1 ng/mg creatinine), b-zearalenol (75%; 0.702 ± 2.95 ng/mg creatinine) and ochratoxin A
(98%; 0.041 ± 0.086 ng/mg creatinine). These demonstrate the value of multi-biomarker methods in
measuring exposures in populations exposed to multiple mycotoxins. This is the first finding of urinary
deoxynivalenol, zearalenone, their conjugates, ochratoxin A and zearalenols in Transkei. (literal)
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