http://www.cnr.it/ontology/cnr/individuo/prodotto/ID27539
Prelamin A is involved in early steps of muscle differentiation. (Articolo in rivista)
- Type
- Label
- Prelamin A is involved in early steps of muscle differentiation. (Articolo in rivista) (literal)
- Anno
- 2008-01-01T00:00:00+01:00 (literal)
- Alternative label
Capanni C, Del Coco R, Squarzoni S, Columbaro M, Mattioli E, Camozzi D, Rocchi A, Scotlandi K, Maraldi N, Foisner R, Lattanzi G. (2008)
Prelamin A is involved in early steps of muscle differentiation.
in Experimental cell research
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Capanni C, Del Coco R, Squarzoni S, Columbaro M, Mattioli E, Camozzi D, Rocchi A, Scotlandi K, Maraldi N, Foisner R, Lattanzi G. (literal)
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- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- IGM-CNR, Unit of Bologna, c/o IOR, Via di Barbiano 1/10 I-40136 Bologna, Italy; Laboratory of Cell Biology Istituto Ortopedico Rizzoli, Bologna, Italy; Laboratory of Oncological Research, Istituto Ortopedico Rizzoli, Bologna, Italy; Max F. Perutz Laboratories, Medical University of Vienna, Vienna, Austria (literal)
- Titolo
- Prelamin A is involved in early steps of muscle differentiation. (literal)
- Abstract
- Lamin A is a nuclear lamina constituent implicated in a number of human disorders including Emery-Dreifuss muscular dystrophy. Since increasing evidence suggests a role of the lamin A precursor in nuclear functions, we investigated the processing of prelamin A during differentiation of C2C12 mouse myoblasts. We show that both protein levels and cellular localization of prelamin A are modulated during myoblast activation. Similar changes of lamin A-binding proteins emerin and LAP2alpha were observed. Furthermore, prelamin A was found in a complex with LAP2alpha in differentiating myoblasts. Prelamin A accumulation in cycling myoblasts by expressing unprocessable mutants affected LAP2alpha and PCNA amount and increased caveolin 3 mRNA and protein levels, while accumulation of prelamin A in differentiated muscle cells following treatment with a farnesyl transferase inhibitor appeared to inhibit caveolin 3 expression. Our data provide evidence for a critical role of the lamin A precursor in the early steps of muscle cell differentiation. (literal)
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