beta-Amyloid Amorphous Aggregates Induced by the Small Natural Molecule Ferulic Acid (Articolo in rivista)

Type
Label
  • beta-Amyloid Amorphous Aggregates Induced by the Small Natural Molecule Ferulic Acid (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/jp4079986 (literal)
Alternative label
  • Bramanti E, Fulgentini L, Bizzarri R, Lenci F, Sgarbossa A (2013)
    beta-Amyloid Amorphous Aggregates Induced by the Small Natural Molecule Ferulic Acid
    in The journal of physical chemistry. B
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Bramanti E, Fulgentini L, Bizzarri R, Lenci F, Sgarbossa A (literal)
Pagina inizio
  • 13816 (literal)
Pagina fine
  • 13821 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://pubs.acs.org/doi/abs/10.1021/jp4079986 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 117 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 44 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • UO Pisa, CNR, Ist Composti Organo Met, I-56124 Pisa, Italy; UO Pisa, CNR, Ist Biofis, I-56124 Pisa, Italy; UO Pisa, CNR, Ist Nazl Ott, I-56124 Pisa, Italy (literal)
Titolo
  • beta-Amyloid Amorphous Aggregates Induced by the Small Natural Molecule Ferulic Acid (literal)
Abstract
  • There is an emerging interest in small natural molecules for their potential therapeutic use in neurodegenerative disorders like Alzheimer's disease (AD). Ferulic acid (FA), an antioxidant phenolic compound present in fruit and vegetables, has been proposed as an inhibitor of beta amyloid (A?) pathological aggregation. Using fluorescence and Fourier transform infrared spectroscopy, electrophoresis techniques, chromatographic analysis, and confocal microscopy, we investigated the effects of FA in the early stages of A? fibrillogenesis in vitro. Our results show that FA interacts promptly with A? monomers/oligomers, interfering since the beginning with its self-assembly and finally forming amorphous aggregates more prone to destabilization. These findings highlight the molecular basis underlying FA antiamyloidogenic activity in AD. (literal)
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