Common variants associated with plasma triglycerides and risk for coronary artery disease. (Articolo in rivista)

Type
Label
  • Common variants associated with plasma triglycerides and risk for coronary artery disease. (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/ng.2795 (literal)
Alternative label
  • Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkilä K, Hyppönen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytikäinen LP, Magnusson PK, Mangino M, Mihailov E, Montasser ME, Müller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney AS, Döring A, Elliott P, Epstein SE, Eyjolfsson GI, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJ, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtimäki T, Lin SY, Lindström J, Loos RJ, Mach F, McArdle WL, Meisinger C, Mitchell BD, Müller G, Nagaraja R, Narisu N, Nieminen TV, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stan?áková A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YD, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferrières J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Järvelin MR, Jula A, Kähönen M, Kaprio J, Kesäniemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, März W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Njølstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PE, Sheu WH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BH, Altshuler D, Ordovas JM, Boerwinkle E, Palmer CN, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Mohlke KL, Ingelsson E, Abecasis GR, Daly MJ, Neale BM, Kathiresan S. (2013)
    Common variants associated with plasma triglycerides and risk for coronary artery disease.
    in Nature genetics (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K, Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkilä K, Hyppönen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen M, Kettunen J, Kleber ME, Li X, Luan J, Lyytikäinen LP, Magnusson PK, Mangino M, Mihailov E, Montasser ME, Müller-Nurasyid M, Nolte IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ, Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL, Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney AS, Döring A, Elliott P, Epstein SE, Eyjolfsson GI, Gigante B, Goodarzi MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL, Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones MR, Kaleebu P, Kastelein JJ, Khaw KT, Kim E, Klopp N, Komulainen P, Kumari M, Langenberg C, Lehtimäki T, Lin SY, Lindström J, Loos RJ, Mach F, McArdle WL, Meisinger C, Mitchell BD, Müller G, Nagaraja R, Narisu N, Nieminen TV, Nsubuga RN, Olafsson I, Ong KK, Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP, Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl H, Seeley J, Silander K, Stan?áková A, Stirrups K, Swift AJ, Tiret L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH, Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier M, Campbell H, Chakravarti A, Chambers JC, Chen YD, Collins FS, Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferrières J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V, Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN, Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K, Iribarren C, Järvelin MR, Jula A, Kähönen M, Kaprio J, Kesäniemi A, Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J, Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, März W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L, Morris AD, Munroe PB, Njølstad I, Pedersen NL, Power C, Pramstaller PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D, Salomaa V, Sanghera DK, Saramies J, Schwarz PE, Sheu WH, Shuldiner AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO, Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P, Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BH, Altshuler D, Ordovas JM, Boerwinkle E, Palmer CN, Thorsteinsdottir U, Chasman DI, Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS, Boehnke M, Deloukas P, Mohlke KL, Ingelsson E, Abecasis GR, Daly MJ, Neale BM, Kathiresan S. (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. Ron Do, Chi Gao & Sekar Kathiresan Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. Ron Do, Chi Gao, Gina M Peloso, Richa Saxena, David Altshuler, Mark J Daly, Benjamin M Neale & Sekar Kathiresan Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. Ron Do, David Altshuler & Sekar Kathiresan Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. Ron Do, Chi Gao, Gina M Peloso, Tõnu Esko, Pierre Fontanillas, Cameron D Palmer, Sailaja Vedantam, Joel N Hirschhorn, David Altshuler, Mark J Daly, Benjamin M Neale & Sekar Kathiresan Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA. Cristen J Willer Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. Cristen J Willer & Ellen M Schmidt Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA. Cristen J Willer Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA. Cristen J Willer, Sebanti Sengupta, Jin Chen, Jennifer L Bragg-Gresham, Anne U Jackson, Carlo Sidore, Tanya M Teslovich, Michael Boehnke & Goncalo R Abecasis Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA. Gina M Peloso & L Adrienne Cupples Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden. Stefan Gustafsson, Andrea Ganna, Ci Song, Agneta Siegbahn & Erik Ingelsson Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Stefan Gustafsson, Andrea Ganna, Ci Song & Erik Ingelsson Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. Stavroula Kanoni, Deepti Gurdasani, Inês Barroso, Theodore Papamarkou, Cristina Pomilla, Kathleen Stirrups, Nicholas Wainwright, Elizabeth H Young, Samuli Ripatti, Manjinder S Sandhu & Panos Deloukas Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Andrea Ganna, Patrik K E Magnusson, Ci Song & Nancy L Pedersen Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. Martin L Buchkovich, Ying Wu & Karen L Mohlke Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Samia Mora, Paul M Ridker & Daniel I Chasman Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Samia Mora, Paul M Ridker & Daniel I Chasman Service of Medical Genetics, Lausanne University Hospital, Lausanne, Switzerland. Jacques S Beckmann Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. Jacques S Beckmann Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Hsing-Yi Chang Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. Ay?e Demirkan, Aaron Isaacs & Cornelia M van Duijn Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands. Heleen M Den Hertog, Evita G Van den Herik & Peter J Koudstaal Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, UK. Louise A Donnelly, Alex S F Doney, Andrew D Morris & Colin N A Palmer Cardiology, Department of Specialities of Medicine, Geneva University Hospital, Geneva, Switzerland. Georg B Ehret & François Mach Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Georg B Ehret & Aravinda Chakravarti Estonian Genome Center of the University of Tartu, Tartu, Estonia. Tõnu Esko, Krista Fischer, Evelin Mihailov, Markus Perola & Andres Metspalu Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. Tõnu Esko, Evelin Mihailov & Andres Metspalu Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA. Mary F Feitosa & Ingrid B Borecki Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Teresa Ferreira, Cecilia M Lindgren, Mark I McCarthy & Erik Ingelsson Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK. Ross M Fraser, Jennifer L Bolton, Igor Rudan, Sarah H Wild, James F Wilson, Harry Campbell & Jackie F Price Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Daniel F Freitag, Deepti Gurdasani, Theodore Papamarkou, Cristina Pomilla, Nicholas Wainwright, Elizabeth H Young, John Danesh, Danish Saleheen & Manjinder S Sandhu Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland. Kauko Heikkilä & Jaakko Kaprio Centre For Paediatric Epidemiology and Biostatistics/Medical Research Council (MRC) Centre of Epidemiology for Child Health, University College London Institute of Child Health, London, UK. Elina Hyppönen & Chris Power Centre for Medical Systems Biology, Leiden, The Netherlands. Aaron Isaacs & Cornelia M van Duijn Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. Åsa Johansson & Ulf Gyllensten Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden. Åsa Johansson, Agneta Siegbahn & Lars Wallentin Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Toby Johnson & Patricia B Munroe Clinical Pharmacology, National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Toby Johnson & Patricia B Munroe Biocenter Oulu, University of Oulu, Oulu, Finland. Marika Kaakinen & Marjo-Riitta Järvelin Institute of Health Sciences, University of Oulu, Oulu, Finland. Marika Kaakinen, Paul Elliott & Marjo-Riitta Järvelin Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. Johannes Kettunen, Markus Perola, Ida Surakka, Aarno Palotie, Kaisa Silander, Jaakko Kaprio & Samuli Ripatti Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland. Johannes Kettunen, Markus Perola, Ida Surakka, Kaisa Silander & Samuli Ripatti Department of Internal Medicine II-Cardiology, University of Ulm Medical Centre, Ulm, Germany. Marcus E Kleber Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany. Marcus E Kleber & Winfried März Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Xiaohui Li, Eric Kim & Jerome I Rotter MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Jian'an Luan, Claudia Langenberg, Ruth J F Loos, Ken K Ong, Jing Hua Zhao & Nicholas J Wareham Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. Leo-Pekka Lyytikäinen & Terho Lehtimäki Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland. Leo-Pekka Lyytikäinen & Terho Lehtimäki Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. Massimo Mangino & Tim D Spector Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, School of Medicine, Baltimore, Maryland, USA. May E Montasser, Jeffrey R O'Connell, Braxton D Mitchell & Alan R Shuldiner Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany. Martina Müller-Nurasyid, Ann-Kristin Petersen & Christian Gieger Department of Medicine I, University Hospital Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany. Martina Müller-Nurasyid Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians University of Munich, Munich, Germany. Martina Müller-Nurasyid Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Ilja M Nolte Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, USA. Cameron D Palmer, Sailaja Vedantam & Joel N Hirschhorn Division of Genetics, Program in Genomics, Children's Hospital Boston, Boston, Massachusetts, USA. Cameron D Palmer, Sailaja Vedantam & Joel N Hirschhorn Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy. Serena Sanna & Carlo Sidore Center for Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California, USA. Susan K Service & Nelson B Freimer Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, UK. Sonia Shah, Meena Kumari, Aroon Hingorani & Mika Kivimaki Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Center, Scania University Hospital, Malmö, Sweden. Dmitry Shungin & Paul W Franks Department of Odontology, UmeÃ¥ University, UmeÃ¥, Sweden. Dmitry Shungin Department of Public Health and Primary Care, Unit of Medicine, UmeÃ¥ University, UmeÃ¥, Sweden. Dmitry Shungin & Paul W Franks Dipartimento di Scienze Biomediche, Universita di Sassari, Sassari, Italy. Carlo Sidore Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. Rona J Strawbridge & Anders Hamsten Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden. Rona J Strawbridge & Anders Hamsten Clinical Research Branch, US National Institutes of Health, Baltimore, Maryland, USA. Toshiko Tanaka & Luigi Ferrucci deCODE Genetics/Amgen, Reykjavik, Iceland. Gudmar Thorleifsson, Hilma Holm, Kari Stefansson & Unnur Thorsteinsdottir Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Benjamin F Voight Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Benjamin F Voight Human Genetics Center, University of Texas Health Science Center, School of Public Health, Houston, Texas, USA. Kelly A Volcik & Eric Boerwinkle HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA. Lindsay L Waite & Devin Absher MRC Unit for Lifelong Health and Ageing, London, UK. Andrew Wong, Ken K Ong & Diana Kuh Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. Weihua Zhang, Paul Elliott, John C Chambers & Marjo-Riitta Järvelin Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. Weihua Zhang, John C Chambers & Jaspal S Kooner Medical Research Council/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda. Gershim Asiki, Pontiano Kaleebu, Rebecca N Nsubuga & Janet Seeley University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Inês Barroso NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Inês Barroso Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. Latonya F Been, Martha L Gravito & Dharambir K Sanghera Genome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA. Lori L Bonnycastle, Narisu Narisu, Amy J Swift & Francis S Collins Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy. Paolo Brambilla MedStar Health Research Institute, Hyattsville, Maryland, USA. Mary S Burnett & Stephen E Epstein Research Centre on Public Health, University of Milano-Bicocca, Monza, Italy. Giancarlo Cesana Department of Dietetics-Nutrition, Harokopio University, Athens, Greece. Maria Dimitriou & George Dedoussis Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg, Germany. Angela Döring & Christa Meisinger Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany. Angela Döring MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK. Paul Elliott & Marjo-Riitta Järvelin The Laboratory in Mjodd, Reykjavik, Iceland. Gudmundur Ingi Eyjolfsson Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Bruna Gigante & Ulf de Faire Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California, USA. Mark O Goodarzi & Michelle R Jones Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany. Harald Grallert, Thomas Illig & Norman Klopp Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. Christopher J Groves & Mark I McCarthy Department of Public Health and Clinical Medicine, Nutritional Research, UmeÃ¥ University, UmeÃ¥, Sweden. Göran Hallmans Department of Clinical Sciences/Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland. Anna-Liisa Hartikainen & Anneli Pouta MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK. Caroline Hayward Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA. Dena Hernandez Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (Affiliated Institute of the University of Lübeck). Andrew A Hicks & Peter P Pramstaller Division of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Yi-Jen Hung Hannover Unified Biobank, Hannover Medical School, Hannover, Germany. Thomas Illig & Norman Klopp Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. John J P Kastelein & G Kees Hovingh Clinical Gerontology Unit, University of Cambridge, Cambridge, UK. Kay-Tee Khaw Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Pirjo Komulainen, Timo A Lakka & Rainer Rauramaa Department of Internal Medicine, Division of Endocrine and Metabolism, Taichung Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Shih-Yi Lin Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland. Jaana Lindström & Jaakko Tuomilehto The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. Ruth J F Loos The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. Ruth J F Loos The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. Ruth J F Loos School of Social and Community Medicine, University of Bristol, Bristol, UK. Wendy L McArdle Institute for Medical Informatics and Biometrics, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany. Gabrielle Müller Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA. Ramaiah Nagaraja Department of Clinical Pharmacology, University of Tampere School of Medicine, Tampere, Finland. Tuomo V M Nieminen Department of Internal Medicine, Päijät-Häme Central Hospital, Lahti, Finland. Tuomo V M Nieminen Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland. Tuomo V M Nieminen Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland. Isleifur Olafsson Department of Medical Genetics, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. Aarno Palotie Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. Aarno Palotie Department of Statistical Sciences, University College London, London, UK. Theodore Papamarkou National Institute for Health and Welfare, Oulu, Finland. Anneli Pouta & Marjo-Riitta Järvelin Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Translational Research Center, Philadelphia, Pennsylvania, USA. Daniel J Rader & Muredach P Reilly Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, Translational Research Center, Philadelphia, Pennsylvania, USA. Daniel J Rader & Muredach P Reilly Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. Fernando Rivadeneira, Andre G Uitterlinden & Albert Hofman Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands. Fernando Rivadeneira & Andre G Uitterlinden Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands. Fernando Rivadeneira, Andre G Uitterlinden & Albert Hofman Department of Clinical Sciences/Clinical Chemistry, University of Oulu, Oulu, Finland. Aimo Ruokonen National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK. Nilesh Samani Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK. Nilesh Samani Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. Hubert Scharnagl & Winfried März School of International Development, University of East Anglia, Norwich, UK. Janet Seeley Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. Alena Stan?áková INSERM UMRS 937, Pierre and Marie Curie University, Paris, France. Laurence Tiret Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. L Joost van Pelt LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. L Joost van Pelt, Cisca Wijmenga & Bruce H R Wolffenbuttel Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Cisca Wijmenga Department of Biological Psychology, VU University, Amsterdam, The Netherlands. Gonneke Willemsen & Dorret I Boomsma Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway. Tom Wilsgaard & Inger Njølstad Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina, USA. Linda S Adair Department of Epidemiology and Public Health, University of Strasbourg, Faculty of Medicine, Strasbourg, France. Dominique Arveiler Department of Medicine, Stanford University School of Medicine, Stanford, California, USA. Themistocles L Assimes & Thomas Quertermous Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy. Stefania Bandinelli Chemical Pathology, Department of Pathology, University of the West Indies, Mona, Jamaica. Franklyn Bennett Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland. Murielle Bochud & Pascal Bovet Department of Internal Medicine, Division of Endocrinology and Diabetes, Ulm University Medical Centre, Ulm, Germany. Bernhard O Boehm Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Bernhard O Boehm Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany. Stefan R Bornstein & Peter E H Schwarz Ministry of Health, Victoria, Republic of Seychelles. Pascal Bovet Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland. Michel Burnier Imperial College Healthcare National Health Service (NHS) Trust, London, UK. John C Chambers & Jaspal S Kooner Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California, USA. Yii-Der Ida Chen Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA. Yii-Der Ida Chen Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois, USA. Richard S Cooper & Bamidele O Tayo Office of Population Studies Foundation, University of San Carlos, Talamban, Cebu City, Philippines. Alan B Feranil Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France. Jean Ferrières Department of Psychiatry, University of California, Los Angeles, Los Angeles, California, USA. Nelson B Freimer Department of Clinical Sciences, Lund University, Malmö, Sweden. Leif C Groop Department of Medicine, Helsinki University Hospital, Helsinki, Finland. Leif C Groop Icelandic Heart Association, Kopavogur, Iceland. Vilmundur Gudnason Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden. Anders Hamsten Laboratory of Epidemiology, Demography and Biometry, National Institute on Ageing, Bethesda, Maryland, USA. Tamara B Harris Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Chao Agnes Hsiung Cardiovascular Genetics, British Heart Foundation Laboratories, Institute Cardiovascular Science, University College London, London, UK. Steve E Humphries Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA. Steven C Hunt Nord-Trøndelag Health Study (HUNT) Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway. Kristian Hveem Kaiser Permanente, Division of Research, Oakland, California, USA. Carlos Iribarren Unit of Primary Care, Oulu University Hospital, Oulu, Finland. Marjo-Riitta Järvelin Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland. Antti Jula Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland. Mika Kähönen Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland. Jaakko Kaprio Institute of Clinical Medicine, Department of Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland. Antero Kesäniemi National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK. Jaspal S Kooner Children's Hospital Oakland Research Institute, Oakland, California, USA. Ronald M Krauss Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. Johanna Kuusisto & Markku Laakso Institute of Regional Health Services Research, University of Southern Denmark, Odense, Denmark. Kirsten O Kyvik Odense Patient Data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark. Kirsten O Kyvik Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. Timo A Lakka Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Lars Lind, Agneta Siegbahn & Lars Wallentin Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Queensland, Australia. Nicholas G Martin & John B Whitfield Synlab Academy, Synlab Services, Mannheim, Germany. Winfried März Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica. Colin A McKenzie INSERM U872, Centre de Recherche des Cordeliers, Paris, France. Pierre Meneton Department of Medicine, Kuopio University Hospital, Kuopio, Finland. Leena Moilanen Department of Neurology, General Central Hospital, Bolzano, Italy. Peter P Pramstaller Department of Neurology, University of Lübeck, Lübeck, Germany. Peter P Pramstaller Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington, USA. Bruce M Psaty Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA. Bruce M Psaty Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland. Rainer Rauramaa Center for Non-Communicable Diseases, Karachi, Pakistan. Danish Saleheen Department of Medicine, University of Pennsylvania, USA. Danish Saleheen Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland. Veikko Salomaa South Karelia Central Hospital, Lappeenranta, Finland. Jouko Saramies Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, Germany. Peter E H Schwarz Department of Internal Medicine, Division of Endocrine and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan. Wayne H-H Sheu Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USA. Alan R Shuldiner Faculty of Medicine, University of Iceland, Reykjavík, Iceland. Kari Stefansson & Unnur Thorsteinsdottir Division of Population Health Sciences and Education, St. George's, University of London, London, UK. David P Strachan Department of Pharmacological Sciences, University of Milan, Monzino Cardiology Center, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy. Elena Tr????????????????‘ê??????ðŒ4????????????aê??????Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. Ron Do, Chi Gao & Sekar Kathiresan Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. Ron Do, Chi Gao, Gina M Peloso, Richa Saxena, David Altshuler, Mark J Daly, Benjamin M Neale & Sekar Kathiresan Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. Ron Do, David Altshuler & Sekar Kathiresan Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. Ron Do, Chi Gao, Gina M Peloso, Tõnu Esko, Pierre Fontanillas, Cameron D Palmer, Sailaja Vedantam, Joel N Hirschhorn, David Altshuler, Mark J Daly, Benjamin M Neale & Sekar Kathiresan Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA. Cristen J Willer Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. Cristen J Willer & Ellen M Schmidt Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA. Cristen J Willer Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA. Cristen J Willer, Sebanti Sengupta, Jin Chen, Jennifer L Bragg-Gresham, Anne U Jackson, Carlo Sidore, Tanya M Teslovich, Michael Boehnke & Goncalo R Abecasis Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA. Gina M Peloso & L Adrienne Cupples Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden. Stefan Gustafsson, Andrea Ganna, Ci Song, Agneta Siegbahn & Erik Ingelsson Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Stefan Gustafsson, Andrea Ganna, Ci Song & Erik Ingelsson Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. Stavroula Kanoni, Deepti Gurdasani, Inês Barroso, Theodore Papamarkou, Cristina Pomilla, Kathleen Stirrups, Nicholas Wainwright, Elizabeth H Young, Samuli Ripatti, Manjinder S Sandhu & Panos Deloukas Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Andrea Ganna, Patrik K E Magnusson, Ci Song & Nancy L Pedersen Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. Martin L Buchkovich, Ying Wu & Karen L Mohlke Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Samia Mora, Paul M Ridker & Daniel I Chasman Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Samia Mora, Paul M Ridker & Daniel I Chasman Service of Medical Genetics, Lausanne University Hospital, Lausanne, Switzerland. Jacques S Beckmann Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. Jacques S Beckmann Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Hsing-Yi Chang Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. Ay?e Demirkan, Aaron Isaacs & Cornelia M van Duijn Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands. Heleen M Den Hertog, Evita G Van den Herik & Peter J Koudstaal Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, UK. Louise A Donnelly, Alex S F Doney, Andrew D Morris & Colin N A Palmer Cardiology, Department of Specialities of Medicine, Geneva University Hospital, Geneva, Switzerland. Georg B Ehret & François Mach Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Georg B Ehret & Aravinda Chakravarti Estonian Genome Center of the University of Tartu, Tartu, Estonia. Tõnu Esko, Krista Fischer, Evelin Mihailov, Markus Perola & Andres Metspalu Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. Tõnu Esko, Evelin Mihailov & Andres Metspalu Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA. Mary F Feitosa & Ingrid B Borecki Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Teresa Ferreira, Cecilia M Lindgren, Mark I McCarthy & Erik Ingelsson Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK. Ross M Fraser, Jennifer L Bolton, Igor Rudan, Sarah H Wild, James F Wilson, Harry Campbell & Jackie F Price Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Daniel F Freitag, Deepti Gurdasani, Theodore Papamarkou, Cristina Pomilla, Nicholas Wainwright, Elizabeth H Young, John Danesh, Danish Saleheen & Manjinder S Sandhu Hjelt Institute, Department of Public Health, University of Helsinki, Helsinki, Finland. Kauko Heikkilä & Jaakko Kaprio Centre For Paediatric Epidemiology and Biostatistics/Medical Research Council (MRC) Centre of Epidemiology for Child Health, University College London Institute of Child Health, London, UK. Elina Hyppönen & Chris Power Centre for Medical Systems Biology, Leiden, The Netherlands. Aaron Isaacs & Cornelia M van Duijn Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. Åsa Johansson & Ulf Gyllensten Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden. Åsa Johansson, Agneta Siegbahn & Lars Wallentin Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Toby Johnson & Patricia B Munroe Clinical Pharmacology, National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. Toby Johnson & Patricia B Munroe Biocenter Oulu, University of Oulu, Oulu, Finland. Marika Kaakinen & Marjo-Riitta Järvelin Institute of Health Sciences, University of Oulu, Oulu, Finland. Marika Kaakinen, Paul Elliott & Marjo-Riitta Järvelin Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. Johannes Kettunen, Markus Perola, Ida Surakka, Aarno Palotie, Kaisa Silander, Jaakko Kaprio & Samuli Ripatti Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland. Johannes Kettunen, Markus Perola, Ida Surakka, Kaisa Silander & Samuli Ripatti Department of Internal Medicine II-Cardiology, University of Ulm Medical Centre, Ulm, Germany. Marcus E Kleber Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany. Marcus E Kleber & Winfried März Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Xiaohui Li, Eric Kim & Jerome I Rotter MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Jian'an Luan, Claudia Langenberg, Ruth J F Loos, Ken K Ong, Jing Hua Zhao & Nicholas J Wareham Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. Leo-Pekka Lyytikäinen & Terho Lehtimäki Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland. Leo-Pekka Lyytikäinen & Terho Lehtimäki Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. Massimo Mangino & Tim D Spector Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, School of Medicine, Baltimore, Maryland, USA. May E Montasser, Jeffrey R O'Connell, Braxton D Mitchell & Alan R Shuldiner Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany. Martina Müller-Nurasyid, Ann-Kristin Petersen & Christian Gieger Department of Medicine I, University Hospital Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany. Martina Müller-Nurasyid Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians University of Munich, Munich, Germany. Martina Müller-Nurasyid Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Ilja M Nolte Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, USA. Cameron D Palmer, Sailaja Vedantam & Joel N Hirschhorn Division of Genetics, Program in Genomics, Children's Hospital Boston, Boston, Massachusetts, USA. Cameron D Palmer, Sailaja Vedantam & Joel N Hirschhorn Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy. Serena Sanna & Carlo Sidore Center for Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California, USA. Susan K Service & Nelson B Freimer Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London, UK. Sonia Shah, Meena Kumari, Aroon Hingorani & Mika Kivimaki Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Center, Scania University Hospital, Malmö, Sweden. Dmitry Shungin & Paul W Franks Department of Odontology, UmeÃ¥ University, UmeÃ¥, Sweden. Dmitry Shungin Department of Public Health and Primary Care, Unit of Medicine, UmeÃ¥ University, UmeÃ¥, Sweden. Dmitry Shungin & Paul W Franks Dipartimento di Scienze Biomediche, Universita di Sassari, Sassari, Italy. Carlo Sidore Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. Rona J Strawbridge & Anders Hamsten Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden. Rona J Strawbridge & Anders Hamsten Clinical Research Branch, US National Institutes of Health, Baltimore, Maryland, USA. Toshiko Tanaka & Luigi Ferrucci deCODE Genetics/Amgen, Reykjavik, Iceland. Gudmar Thorleifsson, Hilma Holm, Kari Stefansson & Unnur Thorsteinsdottir Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Benjamin F Voight Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. Benjamin F Voight Human Genetics Center, University of Texas Health Science Center, School of Public Health, Houston, Texas, USA. Kelly A Volcik & Eric Boerwinkle HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA. Lindsay L Waite & Devin Absher MRC Unit for Lifelong Health and Ageing, London, UK. Andrew Wong, Ken K Ong & Diana Kuh Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. Weihua Zhang, Paul Elliott, John C Chambers & Marjo-Riitta Järvelin Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK. Weihua Zhang, John C Chambers & Jaspal S Kooner Medical Research Council/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda. Gershim Asiki, Pontiano Kaleebu, Rebecca N Nsubuga & Janet Seeley University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Inês Barroso NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK. Inês Barroso Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. Latonya F Been, Martha L Gravito & Dharambir K Sanghera Genome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA. Lori L Bonnycastle, Narisu Narisu, Amy J Swift & Francis S Collins Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy. Paolo Brambilla MedStar Health Research Institute, Hyattsville, Maryland, USA. Mary S Burnett & Stephen E Epstein Research Centre on Public Health, University of Milano-Bicocca, Monza, Italy. Giancarlo Cesana Department of Dietetics-Nutrition, Harokopio University, Athens, Greece. Maria Dimitriou & George Dedoussis Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg, Germany. Angela Döring & Christa Meisinger Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany. Angela Döring MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK. Paul Elliott & Marjo-Riitta Järvelin The Laboratory in Mjodd, Reykjavik, Iceland. Gudmundur Ingi Eyjolfsson Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Bruna Gigante & Ulf de Faire Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California, USA. Mark O Goodarzi & Michelle R Jones Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany. Harald Grallert, Thomas Illig & Norman Klopp Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. Christopher J Groves & Mark I McCarthy Department of Public Health and Clinical Medicine, Nutritional Research, UmeÃ¥ University, UmeÃ¥, Sweden. Göran Hallmans Department of Clinical Sciences/Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland. Anna-Liisa Hartikainen & Anneli Pouta MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK. Caroline Hayward Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA. Dena Hernandez Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (Affiliated Institute of the University of Lübeck). Andrew A Hicks & Peter P Pramstaller Division of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. Yi-Jen Hung Hannover Unified Biobank, Hannover Medical School, Hannover, Germany. Thomas Illig & Norman Klopp Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. John J P Kastelein & G Kees Hovingh Clinical Gerontology Unit, University of Cambridge, Cambridge, UK. Kay-Tee Khaw Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. Pirjo Komulainen, Timo A Lakka & Rainer Rauramaa Department of Internal Medicine, Division of Endocrine and Metabolism, Taichung Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan. Shih-Yi Lin Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland. Jaana Lindström & Jaakko Tuomilehto The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. Ruth J F Loos The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. Ruth J F Loos The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, USA. Ruth J F Loos School of Social and Community Medicine, University of Bristol, Bristol, UK. Wendy L McArdle Institute for Medical Informatics and Biometrics, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany. Gabrielle Müller Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA. Ramaiah Nagaraja Department of Clinical Pharmacology, University of Tampere School of Medicine, Tampere, Finland. Tuomo V M Nieminen Department of Internal Medicine, Päijät-Häme Central Hospital, Lahti, Finland. Tuomo V M Nieminen Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland. Tuomo V M Nieminen Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland. Isleifur Olafsson Department of Medical Genetics, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. Aarno Palotie Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. Aarno Palotie Department of Statistical Sciences, University College London, London, UK. Theodore Papamarkou National Institute for Health and Welfare, Oulu, Finland. Anneli Pouta & Marjo-Riitta Järvelin Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Translational Research Center, Philadelphia, Pennsylvania, USA. Daniel J Rader & Muredach P Reilly Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, Translational Research Center, Philadelphia, Pennsylvania, USA. Daniel J Rader & Muredach P Reilly Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. Fernando Rivadeneira, Andre G Uitterlinden & Albert Hofman Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands. Fernando Rivadeneira & Andre G Uitterlinden Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands. Fernando Rivadeneira, Andre G Uitterlinden & Albert Hofman Department of Clinical Sciences/Clinical Chemistry, University of Oulu, Oulu, Finland. Aimo Ruokonen National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK. Nilesh Samani Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK. Nilesh Samani Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. Hubert Scharnagl & Winfried März School of International Development, University of East Anglia, Norwich, UK. Janet Seeley Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. Alena Stan?áková INSERM UMRS 937, Pierre and Marie Curie University, Paris, France. Laurence Tiret Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. L Joost van Pelt LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. L Joost van Pelt, Cisca Wijmenga & Bruce H R Wolffenbuttel Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Cisca Wijmenga Department of Biological Psychology, VU University, Amsterdam, The Netherlands. Gonneke Willemsen & Dorret I Boomsma Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway. Tom Wilsgaard & Inger Njølstad Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina, USA. Linda S Adair Department of Epidemiology and Public Health, University of Strasbourg, Faculty of Medicine, Strasbourg, France. Dominique Arveiler Department of Medicine, Stanford University School of Medicine, Stanford, California, USA. Themistocles L Assimes & Thomas Quertermous Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy. Stefania Bandinelli Chemical Pathology, Department of Pathology, University of the West Indies, Mona, Jamaica. Franklyn Bennett Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland. Murielle Bochud & Pascal Bovet Department of Internal Medicine, Division of Endocrinology and Diabetes, Ulm University Medical Centre, Ulm, Germany. Bernhard O Boehm Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Bernhard O Boehm Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany. Stefan R Bornstein & Peter E H Schwarz Ministry of Health, Victoria, Republic of Seychelles. Pascal Bovet Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland. Michel Burnier Imperial College Healthcare National Health Service (NHS) Trust, London, UK. John C Chambers & Jaspal S Kooner Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California, USA. Yii-Der Ida Chen Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA. Yii-Der Ida Chen Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois, USA. Richard S Cooper & Bamidele O Tayo Office of Population Studies Foundation, University of San Carlos, Talamban, Cebu City, Philippines. Alan B Feranil Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France. Jean Ferrières Department of Psychiatry, University of California, Los Angeles, Los Angeles, California, USA. Nelson B Freimer Department of Clinical Sciences, Lund University, Malmö, Sweden. Leif C Groop Department of Medicine, Helsinki University Hospital, Helsinki, Finland. Leif C Groop Icelandic Heart Association, Kopavogur, Iceland. Vilmundur Gudnason Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden. Anders Hamsten Laboratory of Epidemiology, Demography and Biometry, National Institute on Ageing, Bethesda, Maryland, USA. Tamara B Harris Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. Chao Agnes Hsiung Cardiovascular Genetics, British Heart Foundation Laboratories, Institute Cardiovascular Science, University College London, London, UK. Steve E Humphries Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA. Steven C Hunt Nord-Trøndelag Health Study (HUNT) Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway. Kristian Hveem Kaiser Permanente, Division of Research, Oakland, California, USA. Carlos Iribarren Unit of Primary Care, Oulu University Hospital, Oulu, Finland. Marjo-Riitta Järvelin Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland. Antti Jula Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland. Mika Kähönen Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland. Jaakko Kaprio Institute of Clinical Medicine, Department of Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland. Antero Kesäniemi National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK. Jaspal S Kooner Children's Hospital Oakland Research Institute, Oakland, California, USA. Ronald M Krauss Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. Johanna Kuusisto & Markku Laakso Institute of Regional Health Services Research, University of Southern Denmark, Odense, Denmark. Kirsten O Kyvik Odense Patient Data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark. Kirsten O Kyvik Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. Timo A Lakka Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Lars Lind, Agneta Siegbahn & Lars Wallentin Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Queensland, Australia. Nicholas G Martin & John B Whitfield Synlab Academy, Synlab Services, Mannheim, Germany. Winfried März Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica. Colin A McKenzie INSERM U872, Centre de Recherche des Cordeliers, Paris, France. Pierre Meneton Department of Medicine, Kuopio University Hospital, Kuopio, Finland. Leena Moilanen Department of Neurology, General Central Hospital, Bolzano, Italy. Peter P Pramstaller Department of Neurology, University of Lübeck, Lübeck, Germany. Peter P Pramstaller Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington, USA. Bruce M Psaty Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA. Bruce M Psaty Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland. Rainer Rauramaa Center for Non-Communicable Diseases, Karachi, Pakistan. Danish Saleheen Department of Medicine, University of Pennsylvania, USA. Danish Saleheen Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland. Veikko Salomaa South Karelia Central Hospital, Lappeenranta, Finland. Jouko Saramies Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, Germany. Peter E H Schwarz Department of Internal Medicine, Division of Endocrine and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan. Wayne H-H Sheu Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USA. Alan R Shuldiner Faculty of Medicine, University of Iceland, Reykjavík, Iceland. Kari Stefansson & Unnur Thorsteinsdottir Division of Population Health Sciences and Education, St. George's, University of London, London, UK. David P Strachan Department of Pharmacological Sciences, University of Milan, Monzino Cardiology Center, Istituto di Ricovero e Cura a Carattere Scie (literal)
Titolo
  • Common variants associated with plasma triglycerides and risk for coronary artery disease. (literal)
Abstract
  • Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10-8 for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD (literal)
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